Aerobic Oxidation of Propargylic Alcohols to α,β-Unsaturated Alkynals or Alkynones Catalyzed by Fe(NO₃)₃·9H₂O, TEMPO and Sodium Chloride in Toluene

Abstract

A practical aerobic oxidation of propargylic alcohols using Fe(NO₃)₃⋅9H₂O, TEMPO and sodium chloride in toluene at room temperature was applied to various type of propargylic alcohols affording α,β-unsaturated alkynals or alkynones in good to excellent yields. This protocol could be applied in academic laboratories as well as in industrial-scale production.

Key words

aerobic oxidation - propargylic alcohols - catalysis - iron nitrate - TEMPO

• References

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