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Synthesis 2012; 44(10): 1507-1510
DOI: 10.1055/s-0031-1290813
DOI: 10.1055/s-0031-1290813
special topic
Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Alkynes with Aryl Iodides and Vinyl Halides
Further Information
Publication History
Received: 20 February 2012
Accepted: 05 March 2012
Publication Date:
02 April 2012 (online)
Abstract
The microwave-assisted, copper-catalyzed coupling of terminal alkynes with aryl iodides and vinyl halides is reported. In general, the reactions are completed in 10–30 min using 2–5 mol% [CuI(xantphos)] as a catalyst to provide the corresponding alkynes and enynes in good to excellent yields. A broad spectrum of aryl iodides, vinyl iodides, and bromides are coupled with aryl- and alkyl alkynes.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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