1,2-Disubstituted 3-hydroxymethylcyclopropene derivatives have been synthesized by
reacting the dianions of 1-alkyl-3-hydroxymethylcyclopropenes with a range of electrophiles.
Additionally, a complementary procedure is described for one-pot sequential alkylation/rearrangement
to provide a convenient synthesis of a chiral methylenecyclopropane directly from
a 1-alkyl-3-hydroxymethylcyclopropene.
Key words
cyclopropene - chirality - dianions - strained ring systems - rearrangement