An Efficient Synthesis of Azetidines with (2-Bromoethyl)sulfonium Triflate

Abstract

Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure. The high-yielding reaction has a relatively broad scope and was extended to the synthesis of an oxetane.

Key words

annulations - cyclizations - heterocycles - sulfur - ylides

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