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Synthesis 2012; 44(11): 1628-1630
DOI: 10.1055/s-0031-1290985
short paper
© Georg Thieme Verlag Stuttgart · New York

Application of the Kabachnik–Fields and Moedritzer–Irani Procedures for the Preparation of Bis(phosphonomethyl)amino- and Bis[(dimethoxyphosphoryl)­-methyl]amino-Terminated Poly(ethylene glycol)

Cédric-Olivier Turrin*
a   CNRS, Laboratoire de Chimie de Coordination, 205 route de Narbonne, 31077 Toulouse, France
,
Aurélien Hameau
a   CNRS, Laboratoire de Chimie de Coordination, 205 route de Narbonne, 31077 Toulouse, France
,
Anne-Marie Caminade
b   UPS, INPT, LCC, Université de Toulouse, 31077 Toulouse, France, Fax: +33(5)61553003   eMail: turrin@lcc-toulouse.fr
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Publikationsverlauf

Received: 27. Februar 2012

Accepted after revision: 30. März 2012

Publikationsdatum:
02. Mai 2012 (online)

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Abstract

Bis[(dimethoxyphosphoryl)methyl)]amino- and bis(phosphonomethyl)amino-terminated samples of poly(ethylene glycol) (PEG) were prepared from commercially available PEG in fair-to-good yields by means of adaptations of the Moedritzer–Irani and Kabachnik–Fields procedures, respectively. An alternative route involving silylation of phosphonates and subsequent meth­anolysis to afford phosphonic acid groups was also examined.

Key words

polymers - amines - phosphonates
 

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