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Synlett 2012; 23(10): 1546-1548
DOI: 10.1055/s-0031-1291013
DOI: 10.1055/s-0031-1291013
letter
Continuous Flow Synthesis of Secondary Amides by Tandem Azidation– Amidation of Anilines
Further Information
Publication History
Received: 20 February 2012
Accepted after revision: 23 March 2012
Publication Date:
29 May 2012 (online)
![](https://www.thieme-connect.de/media/synlett/201210/lookinside/thumbnails/10.1055-s-0031-1291013-1.jpg)
Abstract
The continuous flow synthesis of a variety of secondary amides by tandem azidation–amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product.
Key words
flow chemistry - amide synthesis - aromatic azides - azidation–amidation - synthetic methodsSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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