Synthesis 2012; 44(18): 2840-2842
DOI: 10.1055/s-0031-1291151
practical synthetic procedures
© Georg Thieme Verlag Stuttgart · New York

Towards an Efficient Preparation of Hydromorphone

René Csuk*
Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Straße 2, 06120 Halle (Saale), Germany, Fax: +49(345)5527030   eMail: rene.csuk@chemie.uni-halle.de
,
Galina Vasileva
Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Straße 2, 06120 Halle (Saale), Germany, Fax: +49(345)5527030   eMail: rene.csuk@chemie.uni-halle.de
,
Alexander Barthel
Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Kurt-Mothes-Straße 2, 06120 Halle (Saale), Germany, Fax: +49(345)5527030   eMail: rene.csuk@chemie.uni-halle.de
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Publikationsverlauf

Received: 06. März 2012

Accepted after revision: 05. April 2012

Publikationsdatum:
26. Juni 2012 (online)


Dedicated to Prof. Dr. Wolf-Dieter Rudorf on the occasion of his 70th birthday. Ad multos annos!

Abstract

Dihydromorphone was prepared from morphine in high yield, excellent purity, and low residual metal content. The key steps used palladium on porous glass and a modified Oppenauer oxidation, or Wilkinson’s catalyst.

 
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