Learning to perform endoscopic resection of esophageal neoplasia is associated with significant complications even within a structured training program

F. G. I. van Vilsteren; R. E. Pouw; L. A. Herrero; F. P. Peters; R. Bisschops; M. Houben; F. T. M. Peters; B. E. Schenk; B. L. A. M. Weusten; M. Visser; F. J. W. Ten Kate; P. Fockens; E. J. Schoon; J. J. G. H. M. Bergman

doi:10.1055/s-0031-1291384

Endoscopy, Table of Contents

Endoscopy 2012; 44(01): 4-14
DOI: 10.1055/s-0031-1291384

Original article

Learning to perform endoscopic resection of esophageal neoplasia is associated with significant complications even within a structured training program

F. G. I. van Vilsteren

¹Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands

,

R. E. Pouw

¹Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands

,

L. A. Herrero

²Gastroenterology, St Antonius hospital, Nieuwegein, The Netherlands

,

F. P. Peters

¹Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands

,

R. Bisschops

³Gastroenterology, University Medical Center Gasthuisberg Leuven, The Netherlands

,

M. Houben

⁴Gastroenterology, Haga Teaching Hospital Den Haag, The Netherlands

,

F. T. M. Peters

⁵Gastroenterology, University Medical Center Groningen, The Netherlands

,

B. E. Schenk

⁶Gastroenterology, Isala Clinics Zwolle, The Netherlands

,

B. L. A. M. Weusten

²Gastroenterology, St Antonius hospital, Nieuwegein, The Netherlands

,

M. Visser

⁷Pathology, Academic Medical Center, Amsterdam, The Netherlands

,

F. J. W. Ten Kate

⁷Pathology, Academic Medical Center, Amsterdam, The Netherlands

,

P. Fockens

¹Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands

,

E. J. Schoon

⁸Gastroenterology, Catharina Hospital Eindhoven, The Netherlands

,

J. J. G. H. M. Bergman

¹Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands

› Author Affiliations

Abstract

Background and study aims: Endoscopic resection is the cornerstone of endoscopic treatment of esophageal high grade dysplasia or early cancer. Endoscopic resection is, however, a technically demanding procedure, which requires training and expertise. The aim of the current study was to prospectively evaluate efficacy and safety of the first 120 endoscopic resection procedures of early esophageal neoplasia performed by six endoscopists (20 endoscopic resections each) who were participating in an endoscopic resection training program.

Patients and methods: The program consisted of four tri-monthly 1-day courses with lectures, live-demonstrations, hands-on training on anesthetized pigs, and one-on-one hands-on training days. Gastroenterologists from centers with multidisciplinary expertise in upper gastrointestinal oncology participated, together with an endoscopy nurse and a pathologist. Outcome measures were complete endoscopic removal of the target area and acute complications.

Results: A total of 120 consecutive esophageal endoscopic resection procedures (85 ER-cap, 35 multiband mucosectomy [MBM]) were performed by six endoscopists: 109 in Barrett’s esophagus, 11 for squamous neoplasia; 85 piecemeal endoscopic resections (median 3 specimens, interquartile range 2 – 4 specimens). Complete endoscopic removal was achieved in 111 /120 cases (92.5 %). Six perforations occurred (5.0 %): five were effectively treated endoscopically (clips, covered stent), and one patient underwent esophagectomy. There were 11 acute mild bleedings (9.2 %), which were managed endoscopically. Perforations occurred in ER-cap procedures performed by four participants (7.1 % ER-cap vs. 0 % MBM; P = 0.18), and in 1.7 % of the first 10 endoscopic resections and 8.3 % of the second 10 endoscopic resections per endoscopist (P = 0.26).

Conclusion: In this intense, structured training program, the first 120 esophageal endoscopic resections performed by six participants were associated with a 5.0 % perforation rate. Although perforations were adequately managed, performing 20 endoscopic resections may not be sufficient to reach the peak of the learning curve in endoscopic resection.

Full Text

References

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Supplementary Material

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