Geburtshilfe Frauenheilkd 2011; 71 - A8
DOI: 10.1055/s-0031-1292699

Thrombophilic genetic polymorphisms and placental histomorphology in pregnancies conceived by assisted reproductive technology

N Aleksandrova 1, O Baev 2, A Shchegolev 3, E Dubova 3, A Donnikov 4
  • 1Research Center for Obstetrics, Gynecology and Perinatology, IVF, Reproduction, Moscow, Russian Federation
  • 2Research Center for Obstetrics, Gynecology and Perinatology, Maternity Deparment, Moscow, Russian Federation
  • 3Research Center for Obstetrics, Gynecology and Perinatology, Autopsy Department, Moscow, Russian Federation
  • 4Research Center for Obstetrics, Gynecology and Perinatology, Laboratory of Molecular-Genetic Methods, Moscow, Russian Federation

Inherited thrombophilia is a condition that predisposes individuals to thrombosis and thromboembolism particularly during pregnancy. Infarction of maternal placental surface (MFI) and massive perivillous fibrin deposition (MPVFD) represents specific placental lesions associated with recurrent adverse fetal outcomes and maternal thrombophilic condition.

The aim of this study was to evaluate an association between common thrombophilic genetic mutations and specific placental lesions in pregnancies conceived by assisted reproductive technology. We studied incidence of maternal thrombophilias (factor V Leiden (FVL), G20210A prothrombin gene mutation and polymorphisms of the plasminogen activator inhibitor-1 (PAI-1) and genetic variant C677T in methylentetrahydrofolate reductase gene (MTHFR) in MFI (18 cases) and MPVFD (15 cases).

Incidence of inherited thrombophilias was 64% (21 cases), among them PAI-1 polymorphism constituted 57% (12 cases).

Conclusion: Incidence of inherited thrombophilia is high among women who need artificial reproductive technology. Testing for inherited thrombophilia prior entering IVF cycles as well as the use of antepartum anticoagulants may help to prevent placenta-mediated pregnancy complications in this group.