DMW - Deutsche Medizinische Wochenschrift, Table of Contents Dtsch Med Wochenschr 2012; 137(05): 186-189DOI: 10.1055/s-0031-1292891 Infektiologie | Commentary Infektiologie © Georg Thieme Verlag KG Stuttgart · New York Antibiotika – neue und alte Substanzen, rationale Verordnung Antibiotics: new and old drugs, rational prescription K. de With 1 Zentrum Infektiologie und Reisemedizin, Medizinische Universitätsklinik, Freiburg , H. Stocker 2 Klinik für Innere Medizin, Infektiologie und Gastroenterologie, Vivantes- Auguste-Viktoria-Klinikum, Berlin , J. Borde 1 Zentrum Infektiologie und Reisemedizin, Medizinische Universitätsklinik, Freiburg 3 Klinik für Gastroenterologie, Hepatologie und Infektiologie, Ortenau-Klinikum Offenburg-Gengenbach , W. V. Kern 1 Zentrum Infektiologie und Reisemedizin, Medizinische Universitätsklinik, Freiburg › Author Affiliations Recommend Article Abstract Buy Article Schlüsselwörter SchlüsselwörterAntibiotika - Colistin - Betalaktam-Antibiotika - Verordnungsverhalten Keywords Keywordsantibiotics - colistin - beta lactam antibiotics - drug prescription Full Text References Literatur 1 Calmers JD, Singanayagam A, Akram AR et al. Safety und efficacy of CURB65-guided antibiotic therapy in community-acquired pneumonia. J Antimicrob Chemother 2011; 66: 416-423 2 de With K, Kern WV, Meyer E. Antibiotikaverbrauch im Krankenhaus.. In: Bundesamt für Verbraucherschutz und Lebensmittelsicherheit, Paul-Ehrlich-Gesellschaft für Chemotherapie, Infektiologie Freiburg: GERMAP 2010 – Antibiotikaresistenz und -verbrauch . Rheinbach: Antiinfectives Intelligence; 2011: 17-21 3 Dudhani RV, Turnidge JD, Nation RL et al. fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models. J Antimicrob Chemother 2010; 65: 1984-1990 4 Garonzik SM, Li J, Thamlikitkul V et al. Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically-ill patients from a multi-center study provide dosing suggestions for various categories of patients. Antimicrob Agents Chemother 2011; 55: 3284-3294 5 Kaki R, Elligsen M, Walker S et al. Impact of antimicrobial stewardship in critical care. J Antimicrob Chemother 2011; 66: 1223-1230 6 Kasiakou SK, Lawrence KR, Choulis N et al. Continuous versus intermittent intravenous administration of antibacterials with time-dependent action. Drugs 2005; 65: 2499-2511 7 Lim SK, Lee SO, Choi SH et al. The outcomes of using colistin for treating multidrug-resistant Acinetobacter species bloodstream infections. J Korean Med Sci 2011; 26: 325-331 8 Louie TJ, Miller MA, Mullane KM et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med 2011; 364: 422-431 9 Rattanaumpawan P, Lorsutthitham J, Ungprasert P et al. Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria. J Antimicrob Chemother 2010; 65: 2645-2649 10 Roberts JA, Webb S, Paterson D et al. A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics. Crit Care Med 2009; 37: 2071-2078 11 Shields RK, Kwak EJ, Potoski BA et al. High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. Diagn Microbiol Infect Dis 2011; 70: 246-252 12 Taccone FS, Laterre PF, Dugernier T et al. Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care 2010; 14: R126 13 Talpaert MJ, Gopal RaoG, Cooper BS et al. Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection. J Antimicrob Chemother 2011; 66: 2168-2174 14 Tamma PD, Putcha N, Suh YD et al. Does prolonged β-lactam infusion improve clinical outcomes compared to intermittent infusions?. BMC Infect Dis 2011; 11: 181 15 Yost RJ, Cappelletty DM. The retrospective cohort of extended-infusion piperacillin-tazobactam (RECEIPT) study. Pharmacotherapy 2011; 31: 767-775