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Exp Clin Endocrinol Diabetes 2012; 120(03): 128-131
DOI: 10.1055/s-0031-1295403
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Variants of the FTO Gene in Obese Children and their Impact on Body Composition and Metabolism before and after Lifestyle Intervention

J. Schum
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
G. Blumenstock
2   Department of Medical Biometry, Eberhard-Karls-University, Tuebingen, Germany
,
K. Weber
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
R. Schweizer
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
C. Pfaff
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
N. Schurr
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
M. B. Ranke
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
G. Binder
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
S. Ehehalt
1   Pediatric Endocrinology and Diabetes, University Children’s Hospital, Tuebingen, Germany
,
for the DISKUS-Study Group › Author Affiliations
Further Information

Publication History

received 29 July 2011
first decision 30 September 2011

accepted 26 October 2011

Publication Date:
20 December 2011 (online)

Also available at
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Abstract

Objective:

To investigate the impact of variants of the FTO gene (rs1421085, rs17817449, rs9939609) in obese children before and after lifestyle intervention.

Method:

Design: Longitudinal, clinical intervention study with an increase in physical activity, and nutritional recommendations based on the ‘Optimized Mixed Diet for German Children and Adolescents’ (Research Institute of Child Nutrition, Germany). Study population: 75 overweight children (40 male, mean BMI 30.4±5.5 kg/m2, mean age 12.6±2.6 years). Measurements: Genotyping by means of a TaqMan SNP genotyping assay. Lean and fat mass were determined by means of DXA.

Results:

For the whole study population, the 6-month lifestyle intervention resulted in a significant improvement (before intervention minus time point 6 months; mean±SD) in BMI-SDS (0.10±0.17, p<0.001), HOMA (1.41±3.19, p<0.001) and relative fat-mass-SDS (0.09±0.23, p=0.005). Before and after lifestyle intervention, there was no significant difference between heterozygote (n=52) and homozygote (n=21) carriers of the FTO gene in terms of BMI, body composition, and the metabolic profile (Insulin, HOMA, lipids, liver function tests).

Conclusion:

Variants in the FTO gene are common in obese children but have no impact on body composition and metabolism before and after lifestyle intervention.

Key words

FTO gene - body composition - metabolism - children
 

  • References

  • 1 Andreasen CH, Stender-Petersen KL, Mogensen MS et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57: 95-101
    CrossrefPubMedGoogle Scholar
  • 2 Arbeitsgemeinschaft Adipositas im Kindes- und Jungendalter (AGA) Leitlinien. München, 2010. Available at http://www.a-g-a.de/Leitlinies2.pdf
    PubMed
  • 3 Cecil JE, Tavendale R, Watt P et al. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008; 359: 2558-2566
    CrossrefPubMedGoogle Scholar
  • 4 Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39 (06) 724-726
    CrossrefPubMedGoogle Scholar
  • 5 Ehehalt S, Schweizer R, Blumenstock G et al. for the DISKUS Study Group . Investigation of Myostatin Serum Levels Before and After a 6-Month Lifestyle Intervention Program in Obese Children. Exp Clin Endocrinol Diabetes 2011; 119 (04) 238-242
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Fang H, Li Y, Du S et al. Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children. BMC Med Genet 2010; 11: 136
    CrossrefPubMedGoogle Scholar
  • 7 Ehehalt S, Binder G, Schurr N et al. For the DISKUS-Study Group, The functional muscle-bone unit in obese children – altered bone structure leads to normal strength strain index. Exp Clin Endocrinol ­Diabetes 2011; 119 (06) 321-326
    PubMedGoogle Scholar
  • 8 Haupt A, Thamer C, Staiger H et al. Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes 2009; 117: 194-197
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Kersting M, Alexy U, Clausen K. Using the Concept of Food Based Dietary Guidelines to Develop an Optimized Mixed Diet (OMD) for German Children and Adolescents. J Pediatr Gastroenterol Nutr 2005; 40: 301-308
    CrossrefPubMedGoogle Scholar
  • 10 Liu G, Zhu H, Lagou V et al. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet 2010; 11: 57
    PubMedGoogle Scholar
  • 11 Loos RJ, Lindgren CM, Li S et al. Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-775
    CrossrefPubMedGoogle Scholar
  • 12 Müller TD, Hinney A, Scherag A et al. ‘Fat mass and obesity associated’ gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Med Genet 2008; 9: 85
    PubMedGoogle Scholar
  • 13 Obst F, Bös K. Akzeptanz und Wirkung zusätzlicher Sportstunden in der Grundschule. Sportpraxis 1997; 2: 44-48
    PubMedGoogle Scholar
  • 14 Price RA, Li WD, Zhao H. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC Medical Genetics 2008; 9: 4
    PubMedGoogle Scholar
  • 15 Reinehr T, Hinney A, Toschke AM et al. Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. Arch Dis Child 2009; 94 (12) 965-967
    CrossrefPubMedGoogle Scholar
  • 16 Rendo T, Moleres A, Marti Del Moral A. Effects of the FTO gene on lifestyle intervention studies in children. Obes Facts 2009; 2 (06) 393-399
    CrossrefPubMedGoogle Scholar
  • 17 Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO geno is associated with body mass index and predisposes to childhood and adult obesity. Science . . 2007; 316 (5826) 889-894
    PubMed
  • 18 Tanofsky-Kraff M, Han JC, Anandalingam K et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr 2009; 90 (06) 1483-1488
    CrossrefPubMedGoogle Scholar
  • 19 Vimaleswaran KS, Li S, Zhao JH et al. Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr 2009; 90: 425-428
    CrossrefPubMedGoogle Scholar
  • 20 Wangensteen T, Egeland T, Akselsen H et al. FTO genotype and weight gain in obese and normal weight adults from a norwegian population based cohort (the HUNT study). Exp Clin Endocrinol Diabetes 2010; 118: 649-652
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Hakanen M, Raitakari OT, Lchtimaki T et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 2009; 94 (04) 1281-1287
    CrossrefPubMedGoogle Scholar
  • 22 Wardle J, Carnell S, Haworth CM et al. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008; 93: 3640-3643
    CrossrefPubMedGoogle Scholar