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Arzneimittelforschung 2011; 61(7): 382-385
DOI: 10.1055/s-0031-1296215
CNS-active Drugs · Hypnotics · Psychotropics · Sedatives
Editio Cantor Verlag Aulendorf (Germany)

Effect of mangiferin, a naturally occurring glucoxylxanthone, on fear memory in rats

Gilberto L Pardo Andreu
1   Centro de Estudio para las Investigaciones y Evaluaciones Biológicas, Instituto de Farmacia y Alimentos, Universidad de La Habana, Cuba
2   Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
3   Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
,
Natasha Maurmann
2   Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
3   Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4   National Institute for Translational Medicine (INCT-TM), Brazil
,
Gustavo Kellermann Reolon
2   Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
3   Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4   National Institute for Translational Medicine (INCT-TM), Brazil
,
Caroline Brunetto de Farias
2   Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
4   National Institute for Translational Medicine (INCT-TM), Brazil
5   Children’s Cancer Institute (ICI-RS) and Pediatric Oncology Service, Porto Alegre, RS, Brazil
,
René Delgado
6   Centro de Investigación y Desarrollo de Medicamentos (CIDEM), Ciudad Habana, Cuba
,
Rafael Roesler
2   Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
3   Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4   National Institute for Translational Medicine (INCT-TM), Brazil
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Publikationsverlauf

Publikationsdatum:
27. November 2011 (online)

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Abstract

Mangiferin (1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-xanthen-9-one, CAS 4773-96-0), a naturally occurring glucosylxanthone, is widely distributed in higher plants and a constituent of folk medicine. In the present study the effect of systemic administration of mangiferin on behavioural outcomes of neurological function in normal rats was investigated. A single intraperitoneal injection of mangiferin (10, 50 and 100 mg/kg body weight) immediately post-training produced an impairment of long-term memory for aversive training and a reduced freezing in a dose independent manner, when given immediately post-training. The administration of mangiferin 6 h post-training did not affect fear memory. The results indicate that mangiferin might induce deficits of emotionally motivated memory.

Key words

C-glucosylxanthone - Inhibitory avoidance - Mangifera indica L. - Mangiferin - Memory
 

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