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Arzneimittelforschung 2010; 60(11): 654-659
DOI: 10.1055/s-0031-1296343
CNS-active Drugs · Hypnotics · Psychotropics · Sedatives
Editio Cantor Verlag Aulendorf (Germany)

Quantification of quetiapine in human plasma by reverse phase high performance liquid chromatography

Dev Prakash
1   Bioanalytical wing, Manipal AcuNova KH Clinical Research Center, Manipal, Karnataka, India
,
Krishnamurthy Bhat
2   Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
,
Raghavendra Shetty
1   Bioanalytical wing, Manipal AcuNova KH Clinical Research Center, Manipal, Karnataka, India
,
Parveen Chaudhary
2   Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
,
Sri Ram Pathak
2   Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
,
Ghosh Amitabha
1   Bioanalytical wing, Manipal AcuNova KH Clinical Research Center, Manipal, Karnataka, India
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
30. Dezember 2011 (online)

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Abstract

The objective of the present investigation is to develop and validate a simple, economical and reliable high performance liquid chromatography method for the quantification of quetiapine (CAS 111974-72-2) in human plasma with a quantification limit sufficiently low to support pharmacokinetic studies. Imipramine hydrochloride (CAS 113-52-0) was used as internal standard. The validated method allows quantification of quetiapine in 15–1000 ng/mL. The method was shown to be precise (≤ 7% coefficient of variation, CV) and accurate (≤ 10% relative error, RE). The correlation coefficient for quetiapine was > 0.9970. The simplicity of the assay and rapid liquid-liquid extraction make it an attractive procedure in high-throughput bioanalysis of quetiapine.

Key words

Antipsychotics - CAS 113-52-0 - CAS 111974-72-2 Imipramine - Quetiapine, bioanalysis - Reverse phase HPLC with UV detection
 

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