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Arzneimittelforschung 2007; 57(12): 795-803
DOI: 10.1055/s-0031-1296682
Antibiotics · Antimycotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis of Some Novel Quinolines and Pyrimido[4,5-b]quinolines Bearing A Sulfonamide Moiety as Potential Anticancer and Radioprotective Agents

Mostafa M. Ghorab
1   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Fatma A. Ragab
2   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Eman Noaman
3   Department of Radiation Biology, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Helmy I. Heiba
1   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Ebaa M. El-Hossary
1   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
21 December 2011 (online)

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Abstract

Some novel 4-(quinolin-1-yl)-benzenesul-fonamide and 4-(pyrimido[4,5-b]quinolin-10-yl)-benzenesulfonamide derivatives have been synthesized. All the newly synthesized target compounds were subjected to in vitro cytotoxic screening to be evaluated for their anticancer activity against Ehrlich ascites carcinoma cells. Among these new compounds, compounds 9a, 11, 12b, 18 and, in particular, 19 showed promising in vitro cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug. Moreover, compound 8 exhibited in vivo radio-protective activity against γ-irradiation in mice.

Key words

Anticancer agents - Pyrimidoquinolines, anticancer and radioprotective activity, sulfonamide moiety - Quinolines, anticancer and radioprotective activity, sulfonamide moiety - Radioprotective agents