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Arzneimittelforschung 2007; 57(12): 795-803
DOI: 10.1055/s-0031-1296682
DOI: 10.1055/s-0031-1296682
Antibiotics · Antimycotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Synthesis of Some Novel Quinolines and Pyrimido[4,5-b]quinolines Bearing A Sulfonamide Moiety as Potential Anticancer and Radioprotective Agents
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Publikationsverlauf
Publikationsdatum:
21. Dezember 2011 (online)
Abstract
Some novel 4-(quinolin-1-yl)-benzenesul-fonamide and 4-(pyrimido[4,5-b]quinolin-10-yl)-benzenesulfonamide derivatives have been synthesized. All the newly synthesized target compounds were subjected to in vitro cytotoxic screening to be evaluated for their anticancer activity against Ehrlich ascites carcinoma cells. Among these new compounds, compounds 9a, 11, 12b, 18 and, in particular, 19 showed promising in vitro cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug. Moreover, compound 8 exhibited in vivo radio-protective activity against γ-irradiation in mice.