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Arzneimittelforschung 2005; 55(8): 461-465
DOI: 10.1055/s-0031-1296889
Antiemetics · Gastrointestinal Drugs · Uricosuric Drugs · Urologic Drugs
Editio Cantor Verlag Aulendorf (Germany)

Anti-ulcer Actions of Phytosphingosine Hydrochloride in Different Experimental Rat Ulcer Models

Seung Woo Baek
a   Laboratory of Biochemical Engineering, Department of Chemical Engineering, Sung kyun kwan University, Suwon, Korea)
,
Nam Ki Kim
a   Laboratory of Biochemical Engineering, Department of Chemical Engineering, Sung kyun kwan University, Suwon, Korea)
,
Hwan-Jun Jin
a   Laboratory of Biochemical Engineering, Department of Chemical Engineering, Sung kyun kwan University, Suwon, Korea)
,
Chang-Woong Koh
b   Department of Chemical Engineering, Samcheok National University, Samcheok, Korea)
,
Chul Kyung Kim
c   Department of Applied Chemical Engineering, Mokwon University, Daejon, Korea)
,
O-Hyep Kwon
d   Research Institute, KOMA BIOTECH, Seoul, Korea),
,
Jun-Sung Kim
e   Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Korea)
,
Myung-Haing Cho
e   Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Korea)
,
Chan-Koo Park
e   Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Korea)
› Author Affiliations
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Publication History

Publication Date:
23 December 2011 (online)

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Summary

The gastroprotective activity of phytos-phingosine hydrochloride (PS-HCl, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCl were orally administered to rats 30 min before the treatment with HCl/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCl (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCl/ethanol-induced gastric mucosal membrane lesions (20.1-47.8 % inhibition), (2) indo-metacin-induced gastric mucosal membrane lesions (4.6-31.9 % inhibition), (3) duodenal ulcer induced by cysteamine (10–20 % inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9 % inhibition). These results indicate that PS-HCl may be useful for the prevention of gastric ulcer.

Zusammenfassung

Antiulzerative Wirkung von Phytosphingosin-Hydrochlorid bei verschiedenen Rattenulkusmodellen

Die gastroprotektive Wirkung von Phytosphingosin-Hydrochlorid (PS-HCl, CAS 554-62-1) wurde an verschiedenen Modellen experimentell induzierter Magenulzera an Ratten untersucht. PS-HCl (2.5-10 mg/kg) wurde 30 min vor der Behandlung mit HCl/Ethanol, Indometacin oder Cysteamin bzw. nach Abbinden des Pylorus an Ratten verabreicht. Oral an Ratten verabreichtes PS-HCl (2.5-10 mg/ kg) hemmte dosisabhängig die Bildung von 4 Arten akuter Magenulzera: (1) HCl/ Ethanol-induzierte Laesionen der Magenschleimhaut (20,1-47,8 % Hemmung), (2) Indometacin-induzierte Läsionen der Magenschleimhaut (4,6-31,9 % Hemmung), (3) Cysteamin-induzierte Duodenalulzera (10–20 % Hemmung), und (4) Magensäuresekretion und Ulkusbildung nach Abbinden des Pylorus. Diese Ergebnisse deuten darauf hin, daß PS-HCl der Bildung von Magenulzera vorbeugen kann.

Key words

Anti-ulcer drug - CAS 554-62-1 - Phytosphingosine hydrochloride, anti-ulcer action, rat