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Dtsch Med Wochenschr 2011; 136(48): 2458-2460
DOI: 10.1055/s-0031-1297266
DOI: 10.1055/s-0031-1297266
Endokrinologie und Diabetologie | Commentary
Endokrinologie, Osteologie
© Georg Thieme Verlag KG Stuttgart · New York
Innovationen in der Therapie der Osteoporose
Innovations in the treatment of osteoporosisFurther Information
Publication History
Publication Date:
22 November 2011 (online)
Schlüsselwörter
Osteoporose - Denosumab - Kathepsin K - Saracatinib - Sklerostin
Keywords
osteoporosis - denosumab - cathepsin K - saracatinib - sclerostin
Literatur
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- 3 Bone H G, McClung M R, Roux C, Recker R R, Eisman J A, Verbruggen N, Hustad C M, DaSilva C, Santora A C, Ince B A. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density. J Bone Miner Res. 2010; 25 937-947
- 4 Brown J P, Prince R L, Deal C. et al . Comparison of the Effect of denosumab and alendronate on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial. J Bone Miner Res. 2009; 24 153-161
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- 6 Diarra D, Stolina M, Polzer K. et al . Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007; 13 156-163
- 7 Hannon R A, Clack G, Rimmer M, Swaisland A, Lockton J A, Finkelman R D, Eastell R. Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial. J Bone Miner Res. 2010; 25 463-471
- 8 Heath D J, Chantry A D, Buckle C H, Coulton L, Shaughnessy J D Jr, Evans H R, Snowden J A, Stover D R, Vanderkerken K, Croucher P I. Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma. J Bone Miner Res. 2009; 24 425-436
- 9 Hofbauer L C, Heufelder A E. Clinical review 114: hot topic. The role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases. J Clin Endocrinol Metab. 2000; 85 2355-2363
- 10 Kimura S, Nakagawa T, Matsuo Y, Ishida Y, Okamoto Y, Hayashi M. JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats. Eur J Pharmacol. 2011; ; Jul 28. [Epub ahead of print]
- 11 Kramer I, Halleux C, Keller H, Pegurri M, Gooi J H, Weber P B, Feng J Q, Bonewald L F, Kneissel M. Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol. 2010; 30 3071-3085
- 12 Li X, Ominsky M S, Warmington K S. et al . Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res. 2009; 24 578-588
- 13 McClung M R, Lewiecki E M, Cohen S B. et al., AMG 162 Bone Loss Study Group . Denosumab in postmenopausal women with low bone mineral density. N Engl J Med. 2006; 354 821-831
- 14 Padhi D, Jang G, Stouch B, Fang L, Posvar E. Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res. 2011; 26 19-26
- 15 Saftig P, Hunziker E, Everts V, Jones S, Boyde A, Wehmeyer O, Suter A, von Figura K. Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice. Adv Exp Med Biol. 2000; 477 293-303
Prof. Dr. med. Lorenz C. Hofbauer
Bereich Endokrinologie/Diabetes/Knochenerkrankungen
Medizinische
Klinik und Poliklinik III
Technische Universität
Dresden
Fetscherstr. 74
01307 Dresden
Phone: 0351/458-3173
Fax: 0351/458-4309
Email: Lorenz.Hofbauer@uniklinikum-dresden.de