Pharmacopsychiatry 2012; 45(04): 162-163
DOI: 10.1055/s-0031-1297933
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Agomelatine-Induced Akathisia with Concomitant Duloxetine Medication: A Case Report

C. Imboden
1   Psychiatric Services Solothurn, Department of Adult Psychiatry, Solothurn, Switzerland
,
M. Hatzinger
1   Psychiatric Services Solothurn, Department of Adult Psychiatry, Solothurn, Switzerland
2   Medical Faculty, University of Basel, Basel, Switzerland
› Author Affiliations
Further Information

Publication History

received 18 May 2011
revised 27 October 2011

accepted 08 November 2011

Publication Date:
30 January 2012 (online)

Abstract

A 29-year-old depressed, otherwise healthy female patient was treated with agomelatine and duloxetine. She developed subsequent akathisia, which subsided after cessation of agomelatine. As a cause we suggest a pharmacodynamic drug-drug interaction leading to noradrenergic overstimulation. We recommend only gradual dose titration when combining the 2 substances to minimize the risk for side effects.

 
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