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Pharmacopsychiatry 2012; 45(03): 96-99
DOI: 10.1055/s-0031-1297935
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

The Differential Effect of Risperidone and Olanzapine on Insulin Sensitivity after 3 Weeks of Treatment: A HOMA Pilot Study

G. Paslakis
1   Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
,
M. Deuschle
1   Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
,
J. Thome
1   Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
2   Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
S. Rüße
1   Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
,
D. Kopf
1   Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
› Author Affiliations
Further Information

Publication History

received 06 July 2011
revised 16 October 2011

accepted 25 October 2011

Publication Date:
15 December 2011 (online)

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Abstract

Background and Methods:

Patients with an acute psychotic episode underwent HOMA testing for insulin sensitivity (IS) prior to and after 3 weeks of treatment with olanzapine (n=7) or risperidone (n=7).

Results and Discussion:

The HOMA-IS index was reduced in the olanzapine group, but significantly increased in patients treated with risperidone. There was a significant “time×medication” interaction (p=0.03). The BMI significantly increased as a result of both treatments. IS can be acutely ameliorated by antipsychotic treatment with risperidone despite weight increase.

Conclusions:

Compared to risperidone, the IS is impaired after a 3-week treatment with olanzapine. Already short-term antipsychotic treatment may have effects on insulin sensitivity.

Key words

risperidone - olanzapine - HOMA - insulin sensitivity - BMI
 

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