The Differential Effect of Risperidone and Olanzapine on Insulin Sensitivity after 3 Weeks of Treatment: A HOMA Pilot Study

Abstract

Background and Methods:

Patients with an acute psychotic episode underwent HOMA testing for insulin sensitivity (IS) prior to and after 3 weeks of treatment with olanzapine (n=7) or risperidone (n=7).

Results and Discussion:

The HOMA-IS index was reduced in the olanzapine group, but significantly increased in patients treated with risperidone. There was a significant “time×medication” interaction (p=0.03). The BMI significantly increased as a result of both treatments. IS can be acutely ameliorated by antipsychotic treatment with risperidone despite weight increase.

Conclusions:

Compared to risperidone, the IS is impaired after a 3-week treatment with olanzapine. Already short-term antipsychotic treatment may have effects on insulin sensitivity.

Key words

risperidone - olanzapine - HOMA - insulin sensitivity - BMI

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