Scuba Diving Activates Vascular Antioxidant System

A. Sureda; J. M. Batle; M. D. Ferrer; A. Mestre-Alfaro; J. A. Tur; A. Pons

doi:10.1055/s-0031-1297957

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2012; 33(07): 531-536
DOI: 10.1055/s-0031-1297957

Physiology & Biochemistry

Scuba Diving Activates Vascular Antioxidant System

A. Sureda

¹Biochemistry, University of Balearic Islands, Palma de Mallorca, Palma de Mallorca, Spain

,

J. M. Batle

²Hyperbaric Research Institute (MEDISUB), Research Group on Community Nutrition and Oxidative Stress, Laboratory of Physical Activity Sciences, IUNICS, Palma de Mallorca, Spain

,

M. D. Ferrer

¹Biochemistry, University of Balearic Islands, Palma de Mallorca, Palma de Mallorca, Spain

,

A. Mestre-Alfaro

³Research Group on Community Nutrition and Oxidative Stress, Laboratory of Physical Activity Sciences, IUNICS, University of Balearic Islands, Palma de Mallorca, Spain

,

J. A. Tur

³Research Group on Community Nutrition and Oxidative Stress, Laboratory of Physical Activity Sciences, IUNICS, University of Balearic Islands, Palma de Mallorca, Spain

,

A. Pons

¹Biochemistry, University of Balearic Islands, Palma de Mallorca, Palma de Mallorca, Spain

› Institutsangaben

Abstract

The aim was to study the effects of scuba diving immersion on plasma antioxidant defenses, nitric oxide production, endothelin-1 and vascular endothelial growth factor levels. 9 male divers performed an immersion at 50 m depth for a total time of 35 min. Blood samples were obtained before diving at rest, immediately after diving, and 3 h after the diving session. Leukocyte counts, plasma 8oxoHG, malondialdehyde and nitrite levels significantly increased after recovery. Activities of lactate dehydrogenase, creatine kinase, catalase and superoxide significantly increased immediately after diving and these activities remained high after recovery. Plasma myeloperoxidase activity and protein levels and extracellular superoxide dismutase protein levels increased after 3 h. Endothelin-1 concentration significantly decreased after diving and after recovery. Vascular endothelial growth factor concentration significantly increased after diving when compared to pre-diving values, returning to initial values after recovery. Scuba diving at great depth activated the plasma antioxidant system against the oxidative stress induced by elevated pO₂ oxygen associated with hyperbaria. The decrease in endothelin-1 levels and the increase in nitric oxide synthesis could be factors that contribute to post-diving vasodilation. Diving increases vascular endothelial growth factor plasma levels which can contribute to the stimulation of tissue resistance to diving-derived oxidative damage.

Key words

oxidative stress - antioxidant enzymes - hyperbaric oxygen - nitric oxide

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Referenzen

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