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DOI: 10.1055/s-0031-1298147
© Georg Thieme Verlag KG Stuttgart · New York
Sesquiterpene Lactones from Inula hookeri
Publikationsverlauf
received October 5, 2011
revised Nov. 16, 2011
accepted Dec. 12, 2011
Publikationsdatum:
10. Januar 2012 (online)
![](https://www.thieme-connect.de/media/plantamedica/201205/lookinside/thumbnails/10.1055-s-0031-1298147-1.jpg)
Abstract
Four new sesquiterpene lactones, (1S,5R,6S,7S,8R,9R,10S,11S)-6-acetoxy-9-hydroxy-4-oxo-pseudoguai-2(3)-en-12,8-olide (1), (1S,2R,5R,6S,7R,8S,10R)-6-acetoxy-2-ethoxy-4-oxo-pseudoguai-11(13)-en-12,8-olide (2), (1S,2R,5R,6S,7R,8S,10R)-6-acetoxy-2-hydroxy-4-oxo-pseudoguai-11(13)-en-12,8-olide (3), and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide (4), along with 26 known sesquiterpene lactones, were isolated from the whole plants of Inula hookeri C. B. Clarke. Their structures were established based on spectroscopic methods including HRESIMS, 1D and 2D NMR, and CD techniques. All compounds were evaluated for their cytotoxic activities against HepG2, HeLa, PC-3, and MGC-803 cell lines by CCK-8 assay. Some of the isolates, especiallly pseudoguaianolides and guaianolides, exhibited significant cytotoxicities against these four examined cell lines.
Key words
Inula hookeri - Compositae - sesquiterpene lactones - cytotoxicity - CCK-8 assay
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Dr. Hui-Zi Jin
Wei-Dong Zhang
School of Pharmacy
Shanghai Jiao Tong University
Shanghai Dongchuan Rd 800
Shanghai 200240
PR China
Telefon: +86 21 34 20 59 89
Fax: +86 21 34 20 59 89
eMail: kimhz@sjtu.edu.cn
eMail: wdzhangy@hotmail.com