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DOI: 10.1055/s-0031-1298223
© Georg Thieme Verlag KG Stuttgart · New York
Steroidal Glycosides from the Rhizomes of Anemarrhena asphodeloides and Their Antiplatelet Aggregation Activity
Publication History
received October 8, 2011
revised January 4, 2012
accepted January 12, 2012
Publication Date:
03 February 2012 (online)
![](https://www.thieme-connect.de/media/plantamedica/201206/lookinside/thumbnails/10.1055-s-0031-1298223-1.jpg)
Abstract
Five new steroidal glycosides, timosaponin J (1), timosaponin K (2), (25S)-karatavioside C (5), timosaponin L (6), and (25S)-officinalisnin-I (8), together with eight known steroidal saponins, timosaponin E1 (3), purpureagitosid (4), timosaponin BII (7), timosaponin B III (9), anemarrhenasaponin I (10), anemarrhenasaponin III (11), anemarrhenasaponin A2 (12), and timosaponin A III (13), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were elucidated on the basis of spectroscopic and chemical evidence. The aglycones of compounds 1 and 2 are new aglycones. Compounds 1–13 were evaluated for their platelet aggregation activities, and compound 13 exhibited the strongest inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation.
Key words
Anemarrhena asphodeloides - Liliaceae - timosaponins J - K - and L - steroidal glycosides - antiplatelet aggregation activity
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Prof. Dr. Bai-ping Ma
Department of Biotechnology
Beijing Institute of Radiation Medicine
No. 27 Taiping Road
Beijing 100850
People's Republic of China
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