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DOI: 10.1055/s-0031-1298376
© Georg Thieme Verlag KG Stuttgart · New York
Cycloartane Triterpenoids from Cassia occidentalis
Publikationsverlauf
received October 28, 2011
revised February 22, 2012
accepted February 24, 2012
Publikationsdatum:
12. März 2012 (online)
![](https://www.thieme-connect.de/media/plantamedica/201208/lookinside/thumbnails/10.1055-s-0031-1298376-1.jpg)
Abstract
A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I–V (3–7), together with sixteen known compounds. The structures of the isolated compounds were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and chemical methods. Compounds 2 and 5 showed modest anti-HIV-1 activities with EC50 values of 2.23 µM and 4.36 µM, respectively, in comparison to the positive control.
Key words
Cassia occidentalis - Leguminosae - cycloartane triterpenoids - cycloccidentalic acids A and B - cycloccidentalisides I–V
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Prof. Dr. Xiao-Jiang Hao
State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences
132 Lanhei Road
Heilongtan 650204, Kunming
P. R. China
Telefon: +86 871 5 22 32 63
Fax: +86 871 5 22 30 70
eMail: haoxj@mail.kib.ac.cn
Shun-Lin Li
State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences
132 Lanhei Road
Heilongtan 650204, Kunming
P. R. China
Telefon: +86 871 5 22 32 63
Fax: +86 871 5 22 30 70
eMail: lisl@mail.kib.ac.cn