Neolignans and Sesquiterpenes from Cell Cultures of Stellera chamaejasme

Abstract

Two new neolignans (1, 2) and six sesquiterpenes (3–8) were isolated from the cell cultures of Stellera chamaejasme. Their structures and absolute configurations were elucidated by extensive spectroscopic and computational methods. Compound 4 exhibited significant protective effects against CCl₄-induced hepatotoxicity in HepG2 cells, reducing aspartate aminotransferase release by 29.49 % at 10 µM. These compounds have not been isolated from plant material, which implies that in vitro plant cell cultures may offer alternative and effective sources of bioactive natural compounds.

Key words

Stellera chamaejasme L. - Thymelaeaceae - callus cultures - sesquiterpenes - density functional theory - CCl₄-induced hepatotoxicity

References

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