Planta Med 2012; 78(08): 828-833
DOI: 10.1055/s-0031-1298415
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Antimicrobially Active Hederagenin Glycosides from Cephalaria elmaliensis

Nazlı Böke Sarıkahya
1   Department of Chemistry, Faculty of Science, Ege University, Bornova, Izmir, Turkey
,
Süheyla Kırmızıgül
1   Department of Chemistry, Faculty of Science, Ege University, Bornova, Izmir, Turkey
› Institutsangaben
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Publikationsverlauf

received 15. Juli 2011
revised 28. Februar 2012

accepted 08. März 2012

Publikationsdatum:
11. April 2012 (online)

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Abstract

A phytochemical investigation of the aerial parts of Cephalaria elmaliensis resulted in the isolation of ten hederagenin-type triterpene saponins (110) including three new ones, elmalienoside A (1), elmalienoside B (2), elmalienoside C (3), and two known flavonoid glycosides (1112). Their structures were identified by extensive spectroscopic techniques (1D and 2D NMR, HR ESIMS) and chemical evidence. The antimicrobial activity of the extracts and the pure compounds was evaluated by the MIC method. According to the results, all pure compounds including the new ones were found to be very active against both gram-positive and gram-negative bacteria.

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