Spasmolytic and Antinociceptive Activities of Ursolic Acid and Acacetin Identified in Agastache mexicana

María Eva González-Trujano; Rosa Ventura-Martínez; Marco Chávez; Irene Díaz-Reval; Francisco Pellicer

doi:10.1055/s-0031-1298416

Planta Medica, Inhaltsverzeichnis

Planta Med 2012; 78(08): 793-796
DOI: 10.1055/s-0031-1298416

Biological and Pharmacological Activity

Letters

Georg Thieme Verlag KG Stuttgart · New York

Spasmolytic and Antinociceptive Activities of Ursolic Acid and Acacetin Identified in Agastache mexicana

María Eva González-Trujano

¹Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370, México, D. F. México

,

Rosa Ventura-Martínez

²Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán 04510, México, D. F. México

,

Marco Chávez

³Unidad de Investigación en Enfermedades Neurológicas, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, México, D. F. México

,

Irene Díaz-Reval

⁴Centro Universitario de Investigaciones Biomédicas, Universiad de Colima, Av. 25 de Julio 965, Col. Villa Sn Sebastián, Colima, Col. 28045, México

,

Francisco Pellicer

¹Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370, México, D. F. México

› Institutsangaben

Abstract

Agastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of A. mexicana aerial parts. An antinociceptive response was demonstrated in a significant and dose-dependent manner with ursolic acid and acacetin (i. p. and p. o.) in comparison to the analgesic diclofenac by using the writhing test in mice. Moreover, acacetin also produced a significant concentration-dependent spasmolytic response with major efficacy compared to ursolic acid and papaverine by using rings from the isolated guinea pig ileum. These results provide evidence of the presence of two active constituents of Agastache mexicana reinforcing its utility as a therapy for visceral pain as used in traditional medicine.

Key words

acacetin - Agastache mexicana (H. N. K.) Lint & Epling subsp. xolocotziana - Lamiaceae - antinociception - spasmolytic - ursolic acid

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Referenzen

References
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