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Planta Med 2012; 78(08): 807-813
DOI: 10.1055/s-0031-1298439
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Lignans from Schisandra propinqua with Inhibitory Effects on Lymphocyte Proliferation

Mei Na Jin
1   School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
,
Zhi Yao
2   Department of Immunology, Tianjin Medical University, Tianjin, China
,
Yoshihisa Takaishi
3   Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
,
Hong Quan Duan
1   School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
› Author Affiliations
Further Information

Publication History

received 29 May 2011
revised 20 March 2012

accepted 21 March 2012

Publication Date:
12 April 2012 (online)

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Abstract

Seven new dibenzocyclooctadiene lignans, named propinquain E–K, together with 11 known lignans were isolated from the ethanol extract of the roots of Schisandra propinqua subsp. sinensis. The structures of the new compounds were elucidated by spectroscopic methods, including 1H- and 13C-NMR, 2D-NMR, HR ESI-MS, and CD spectra. Two dibenzocyclooctadienes revealed inhibitory effects on lymphocyte proliferation.

Key words

Schisandraceae - Schisandra propinqua subsp. sinensis - dibenzocyclooctadiene lignin - diaryldimethylbutane lignin - lymphocyte proliferation

Supporting Information

 

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