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DOI: 10.1055/s-0031-1299009
Diabetes mellitus Typ 2 und Depressivität: Was ist ursächlich für was?
Eine systematische LiteraturübersichtType 2 diabetes and depressive symptoms – what comes first? A systematic reviewPublication History
19 July 2011
27 October 2011
Publication Date:
06 March 2012 (online)
![](https://www.thieme-connect.de/media/dmw/201211/lookinside/thumbnails/10.1055-s-0031-1299009-1.jpg)
Zusammenfassung
Hintergrund: Diabetes mellitus Typ 2 und Depressivität sind miteinander in ihrem Auftreten assoziiert. Es bleibt die Frage, ob eine der beiden Erkrankungen ursächlich am Auftreten der anderen beteiligt ist.
Methode: Systematische Literaturrecherche in Medline (deutsch und englisch) in Bezug auf prospektive, kontrollierte populationsbasierte Kohortenstudien und Meta-Analysen.
Ergebnisse: Die Studien belegen sowohl eine höhere Auftretenswahrscheinlichkeit von Depressivität bei Patienten mit Typ-2-Diabetes im Vergleich zu Patienten ohne diese Erkrankung als auch eine höhere Auftretenswahrscheinlichkeit von Typ-2-Diabetes bei Patienten mit Depressivität, im Vergleich zu solchen Patienten ohne diese Erkrankung. Allerdings ist die Studienlage zur ersteren Beziehung weniger stabil.
Diskussion: Das Wissen um die ursächliche Komorbidität hat erhebliche Bedeutung für die Versorgung, und verlangt das Erkennen der möglicherweise zugleich vorliegenden anderen Erkrankung.
Abstract
Background: Diabetes mellitus type 2 and depressive symptoms are statistically associated. The question is if one of the two diseases is causal for the other.
Methods: Systematic review using Medline and searching for prospective controlled population based observational studies and meta-analysis in English or German language.
Results: Patients with type 2 diabetes have a higher incidence of depressive symptoms – compared to patients having no diabetes. And patients with depressive symptoms have a higher incidence of type 2 diabetes; however the findings for the first relation are only weak.
Discussion: Knowing about this – even causal – co-morbidity is important in care, including a routine diagnostic approach to find out if the other disease is also present.
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Literatur
- 1 Ali S, Stone MA, Peters JL et al. The prevalence of comorbid depression in adults with type 2 diabetes. A systematic review and meta-analysis. Diabetic Medicine 2006; 23: 1165-1173
- 2 American Diabetes Association 2007. Standards of medical care in diabetes 2007. Diabetes Care 2007; S4-S41
- 3 Anderson RJ, Clouse RE, Freedland KE et al. The prevalence of comorbid depression in adults with diabetes. A meta-analysis. Diabetes Care 2001; 24: 1069-1078
- 4 Atlantis E, Browning C, Sims J et al. Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA). Int J Geriatr Psychiatry 2010; 25: 688-696
- 5 Campayo A, de Jonge P, Roy JF et al. Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry 2010; 167: 580-588
- 6 Champaneri S, Wand GS, Malhotra SS et al. Biological basis of depression in adults with diabetes. Curr Diab Rep 2010; 10: 396-405
- 7 Collins MM, Corcorant P, Perry J. Anxiety and depression symptoms in patients with diabetes. Diabetic Medicine 2009; 26: 153-161
- 8 Demakakos P, Pierce MB, Hardy R. Depressive symptoms and risk of type 2 diabetes in a national sample of middle-aged and older adults. Diabetes Care 2010; 33: 792-797
- 9 Golden SH, Lazo M, Carnethon M et al. Examining a bidirectional association between depressive symptoms and diabetes. JAMA 2008; 299: 2751-2759
- 10 Huang CQ, Dong BR, Lu ZC et al. Chronic diseases and risk for depression in old age: a meta-analysis of published literature. Ageing Res Rev 2010; 9: 131-141
- 11 Karakus MC, Patton LC. Depression and the onset of chronic illness in older adults: a 12 year prospective study. J Behav Health Serv Res 2011; 38: 373-382
- 12 Knol MJ, Twisk JWR, Beekman ATF et al. Depression as a risk factor for onset of type 2 diabetes. A meta-analysis. Diabetologia 2006; 49: 837-845
- 13 Li C, Ford ES, Strine TW et al. Prevalence of depression among US adults with diabetes. Findings from the 2006 Behavioral Risk Factor Surveillance System. Diabetes Care 2008; 31: 105-107
- 14 Mezuk B, Eaton WW, Albrecht S et al. Depression and type 2 diabetes mellitus over a lifespan: a-meta-analysis. Diabetes Care 2008; 31: 2383-2391
- 15 Moher D, Liberati A, Tetzlaff J. The PRISMA Group et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. PLoS Med 2009; 6: e1000097
- 16 Musselman DL, Betan E, Larsen H et al. Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biol Psychiatry 2003; 54: 317-329
- 17 Nichols GA, Brown JB. Unadjusted and adjusted prevalence of diagnosed depression in type 2 diabetes. Diabetes Care 2003; 26: 744-749
- 18 Nouwen A, Winkley K, Twisk J et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia 2010; 53: 2480-2486
- 19 Pan A, Lucas M, Sun Q et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Archives of Internal Medicine 2010; 170: 1884-1891
- 20 Prestele S, Aldenhoff J, Reiff J. Die HPA-Achse als mögliches Bindeglied zwischen Depression, Diabetes mellitus und kognitiven Störungen. Fortschritte der Neurologie Psychiatrie 2003; 71: 24-36
- 21 Regen F, Merkl A, Heuser I et al. Diabetes und Depression. Dtsch Med Wochenschr 2005; 130: 1097-1102
- 22 Rustad JK, Musselman DL, Nemeroff CB. The relationship of depression and diabetes: pathophysiological and treatment implications. Psychoneuroendocrinology 2011; 36: 1276-1286