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Arzneimittelforschung 2002; 52(3): 205-210
DOI: 10.1055/s-0031-1299881
Analgesics · Antiphlogistics · Antirheumatic Drugs
Editio Cantor Verlag Aulendorf (Germany)

Nitric Oxide Release from Coumarin 4-Carboxamidoximes in the Presence of Thiols

Christos A. Kontogiorgis
Department of Pharmaceutical Chemistry, School of Pharmacy (Chairman: Prof. E. C. Georgarakis), Aristotelian University of Thessaloniki, Thessaloniki, Greece
,
Dimitra J. Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy (Chairman: Prof. E. C. Georgarakis), Aristotelian University of Thessaloniki, Thessaloniki, Greece
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Publication History

Publication Date:
26 December 2011 (online)

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Summary

Coumarin 4-carboxamides with potent anti-inflammatory activity were studied for nitric oxide release in the presence of thiol cofactors in vitro. It was found that NO2 − release was dependent on the nature of thiol.

Zusammenfassung

Stickoxid-Freisetzung aus Coumarin-4-carboxamidoximen in Gegenwart von Thiolen

Coumarin-4-carboxamidoxime mit hoher entzündungshemmender Wirkung wurden im Hinblick auf die Stickoxid-Freisetzung in Gegenwart von Thiolen in vitro untersucht. Die erhaltenen Daten zeigen, daß die Struktur der Thiole eine wichtige Rolle bei der Stickoxid-Freisetzung spielen.

Key words

Anti-inflammatories - Coumarin 4-carboxamides, nitric oxide release - Thiol cofactors