Download PDF
Arzneimittelforschung 2001; 51(7): 569-573
DOI: 10.1055/s-0031-1300081
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Anthelmintic Activity of 3,6-Disubstituted-7H-s-triazolo(3,4-b) (1,3,4) thiadiazines

Bharati A. Nadkarni
a   Department of Chemotherapy Haffkine Institute, Mumbai, India
,
Vijayalaxmi R. Kamat
a   Department of Chemotherapy Haffkine Institute, Mumbai, India
,
Barsu G. Khadse
a   Department of Chemotherapy Haffkine Institute, Mumbai, India
› Author Affiliations
Further Information

Publication History

Publication Date:
26 December 2011 (online)

  PDF Download  Permissions and Reprints

Summary

A series of 3,6-disubstituted-7H-s-triazolo(3,4-b)(l,3,4)thiadiazines was synthesized by the condensation of the appropriate 3-substituted-4-amino-5-mercapto (1,2,4) triazoles with substituted phena-cyl bromides in alcoholic medium. These compounds have been studied for their in vivo anthelmintic activity in albino mice. A number of compounds showed promising activity when given by the oral route.

Zusammenfassung

Synthese und anthelminthische Aktivität von 3,6-Disubstituierten-7H-s-triazolo (3,4-b) (l,3,4)thiadiazinen

Die Kondensation von 3-substituierten-4-amio-5-mercapto(l,2,4)traizolen mit substituierten Phenylacylbromiden unter Alkohol führte zu einer Reihe von 3,6-disubstituierten-7H-s-triazolo(3,4-b) (l,3,4)thiadiazinen. Einige der Verbindungen zeigten bei In-vivo-Studien an Mäusealbinos nach oraler Applikation eine vielversprechende anthelminthisch Aktivität.

Key words

Anthelmintics - Hymenolepis nana - Triazolo-thiadiazines, anthelmintic activity, mouse, synthesis