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Arzneimittelforschung 2000; 50(7): 626-630
DOI: 10.1055/s-0031-1300261
Antidiabetics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Hypoglycemic Activity of Some New Flavone Derivatives

3rd Communication: 3’-Flavonyl-2,4-thiazolidinediones1)
Oya Bozdağ
a   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
,
Eugen J Verspohl
b   Department of Pharmacology, Institute of Medicinal Chemistry, Münster University, Münster, Germany
,
Rahmiye Ertan
a   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
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Publikationsverlauf

Publikationsdatum:
27. Dezember 2011 (online)

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Summary

A new series of 3’-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized and their chemical structures have been elucidated by various spectral data. The prepared compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1 and 2. In contrast compounds 4, 7 and 8 were able to increase insulin release compared with glibenclamide.

Zusammenfassung

Synthese und blutzuckersenkende Wirkung einiger neuer Flavon-Derivate /3. Mitteilung: 3 ‘-Flavonyl-2,4-thiazolidindione

Eine neue Serie von Flavon-Derivaten (3’-Flavonyl-2,4-thiazolidindione, 2,4-Imidazolidindione und 2-Thiohydantoin-Derivate) (1-10) wurden synthetisiert und ihre chemischen Strukturen durch verschiedene spektrale Daten charakterisiert. Substanzen 1 und 2 hemmten die Glukose-stimulierte Insulinsekretion; demgegenüber hatten Substanzen 4, 7 und 8 einen insulinotropen Effekt, in der Wirkungsstärke vergleichbar mit Glibenclamid.

Key words

Antidiabetic agents - Diabetes mellitus, insulin secretion - Flavone derivatives 2,4-Thiazolidinediones
1)

2nd Communication see Arzneim.-Forsch./Drug Res. 50 (I), 539–543 (2000).