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Int J Sports Med 2012; 33(05): 410-414
DOI: 10.1055/s-0031-1301317
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Mitochondrial Macrohaplogroup Associated with Muscle Power in Healthy Adults

N. Fuku
1   Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
,
H. Murakami
2   Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan
,
M. Iemitsu
3   Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan
,
K. Sanada
3   Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan
,
M. Tanaka
1   Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
,
M. Miyachi
2   Department of Health Promotion and Exercise, National Institute of Health and Nutrition, Tokyo, Japan
› Author Affiliations
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Publication History



accepted after revision 12 December 2011

Publication Date:
29 February 2012 (online)

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Abstract

The present study was undertaken to examine the effect of mitochondrial haplogroups on aerobic and anaerobic performance phenotypes such as maximum oxygen consumption, muscle power, and muscle mass. We recruited 474 healthy Japanese individuals and measured their physical performance phenotypes such as peak oxygen uptake, muscle power, and muscle mass. The genotypes for 186 polymorphisms in the mitochondrial DNA were determined, and the haplotypes were classified into 2 macrohaplogroups (i. e., N and M) and 12 haplogroups (i. e., F, B, A, N9a, N9b, M7a, M7b, G1, G2, D4a, D4b, and D5). When we compared the 2 major Japanese macrohaplogroups, leg extension power (P=0.0395), leg extension power based on body weight (P=0.0343), and vertical jump performance (P=0.0485) were significantly higher in subjects with mitochondrial macrohaplogroup N than in those with macrohaplogroup M. However, peak oxygen uptake was similar between the 2 groups. When we analyzed the 12 haplogroups, all of the measured parameters were similar among them. In conclusion, mitochondrial macrohaplogroup N may be one of the determinant factors of anaerobic physical performance phenotype such as muscle power.

Key words

mtDNA - polymorphism - haplogroup - physical fitness - leg extension power - vertical jump
 

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