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J Neurol Surg Rep 2012; 73(01): 014-018
DOI: 10.1055/s-0032-1301406
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Jugular Foramen Syndrome as Initial Presentation of Metastatic Lung Cancer

Dustin Hayward
1   Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois
,
Christopher Morgan
2   Department of Neurology, Loyola University Medical Center, Maywood, Illinois
,
Bahman Emami
3   Department of Radiation Oncology, Loyola University Medical Center, Maywood, Illinois
,
Jose Biller
2   Department of Neurology, Loyola University Medical Center, Maywood, Illinois
,
Vikram C. Prabhu
3   Department of Radiation Oncology, Loyola University Medical Center, Maywood, Illinois
› Author Affiliations
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Publication History

08 September 2011

23 September 2011

Publication Date:
17 February 2012 (online)

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Abstract

Metastatic involvement of the cranial base and jugular foramen generally presents with headache and lower cranial neuropathy but may escape early diagnosis. In this report, a patient developed a jugular foramen syndrome as the initial presentation of metastatic lung cancer soon after being diagnosed and treated surgically for extracranial atherosclerotic internal carotid artery disease. With the appropriate diagnosis established, he underwent local fractionated radiation therapy and systemic chemotherapy but succumbed to the disease. This report analyses metastatic disease affecting the cranial base and in particular, the jugular foramen, with a discussion of the clinical syndromes that accompany this rare condition.

Keywords

skull base metastasis - cranial nerve palsy - Collet–Sicard syndrome - soil and seed hypothesis
 

  • References

  • 1 Dichiro G, Fisher RL, Nelson KB. The jugular foramen. J Neurosurg 1964; 21: 447-460
    CrossrefPubMedGoogle Scholar
  • 2 Rhoton AL. Cranial Anatomy and Surgical Approaches. Hagerstown, MD: Lippincott Williams & Wilkins; 2003
    Google Scholar
  • 3 Graus F, Slatkin NE. Papilledema in the metastatic jugular foramen syndrome. Arch Neurol 1983; 40 (13) 816-818
    CrossrefPubMedGoogle Scholar
  • 4 Löwenheim H, Koerbel A, Ebner FH, Kumagami H, Ernemann U, Tatagiba M. Differentiating imaging findings in primary and secondary tumors of the jugular foramen. Neurosurg Rev 2006; 29 (1) 1-11, discussion 12–13
    CrossrefPubMedGoogle Scholar
  • 5 Osborne AG. Diagnostic Neuroradiology. Philadelphia, PA: Mosby Inc.; 1994
    Google Scholar
  • 6 McDermott RS, Anderson PR, Greenberg RE, Milestone BN, Hudes GR. Cranial nerve deficits in patients with metastatic prostate carcinoma: clinical features and treatment outcomes. Cancer 2004; 101 (7) 1639-1643
    CrossrefPubMedGoogle Scholar
  • 7 Bone I, Hadley DM. Syndromes of the orbital fissure, cavernous sinus, cerebellopontine angle, and skull base. J Neurol Neurosurg Psychiatry 2005; 76 (Suppl III) 29-38
    PubMedGoogle Scholar
  • 8 Robbins KT, Fenton RS. Jugular foramen syndrome. J Otolaryngol 1980; 9 (6) 505-516
    PubMedGoogle Scholar
  • 9 Carroll CG, Campbell WW. Multiple cranial neuropathies. Semin Neurol 2009; 29 (1) 53-65
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Greenberg HS, Deck MD, Vikram B, Chu FC, Posner JB. Metastasis to the base of the skull: clinical findings in 43 patients. Neurology 1981; 31 (5) 530-537
    CrossrefPubMedGoogle Scholar
  • 11 Streitmann MJ, Sismanis A. Metastatic carcinoma of the temporal bone. Am J Otol 1996; 17 (5) 780-783
    PubMedGoogle Scholar
  • 12 Laigle-Donadey F, Taillibert S, Martin-Duverneuil N, Hildebrand J, Delattre JY. Skull-base metastases. J Neurooncol 2005; 75 (1) 63-69
    CrossrefPubMedGoogle Scholar
  • 13 Schmidt F, Dihné M, Steinbach J, Bühring U, Küker W. [Raeder- and Collet-Siccard-Syndrome. Acute pareses of cranial nerves symptomatic of a dissection of internal carotid artery]. Nervenarzt 2000; 71 (6) 502-505
    CrossrefPubMedGoogle Scholar
  • 14 Greenberg MS. Handbook of Neurosurgery. New York: Thieme Medical Publishers; 2006
    Google Scholar
  • 15 Biller J, Brazis PW, Masdeu JC. Localization in Clinical Neurology. Hagerstown, MD: Lippincott Williams & Wilkins; 2011
    Google Scholar
  • 16 Shine NP, O’Sullivan P. Collet-Sicard syndrome: a rare presentation of metastatic prostate adenocarcinoma. Auris Nasus Larynx 2005; 32 (3) 315-318
    CrossrefPubMedGoogle Scholar
  • 17 Agarwal A, Baisakhiya N, Kakani A, Bhake A, Nagrale M, Reddy S. Metastatic lung cancer presenting with jugular foramen syndrome in a case of von Recklinghausens disease. J Cancer Res Ther 2010; 6 (3) 391-393
    CrossrefPubMedGoogle Scholar
  • 18 Schweinfurth JM, Johnson JT, Weissman J. Jugular foramen syndrome as a complication of metastatic melanoma. Am J Otolaryngol 1993; 14 (3) 168-174
    CrossrefPubMedGoogle Scholar
  • 19 Soffietti R, Rudā R, Mutani R. Management of brain metastases. J Neurol 2002; 249 (10) 1357-1369
    CrossrefPubMedGoogle Scholar