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Semin intervent Radiol 2012; 29(01): 052-056
DOI: 10.1055/s-0032-1302452
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Aggressive Management of Pulmonary Embolism

Nael Saad
1   Department of Radiology & Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
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Publication History

Publication Date:
16 April 2012 (online)

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Abstract

Pulmonary embolism (PE) and deep vein thrombosis are two elements of the same pathophysiological process referred to as venous thromboembolism. PE occurs when a thrombus migrates from a deep vein to the pulmonary arteries. Although the true incidence of PE is not known, it is estimated that 530,000 cases of PE occur annually in the United States. Clinical presentation varies from asymptomatic (incidentally diagnosed) to fatal. Development of symptoms depends on the embolic burden and the severity of any underlying cardiopulmonary disease. Several treatment options are available for patients diagnosed with PE. The mainstay of treatment is anticoagulation, but given the high mortality associated with some presentations of symptomatic PE, some advocate more aggressive therapy. In this article we discuss such therapies and their potential and appropriate use.

Keywords

pulmonary embolism - thrombolysis - catheter-directed thrombolysis - pharmaco-mechanical thrombolysis
 

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