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Exp Clin Endocrinol Diabetes 2012; 120(04): 191-193
DOI: 10.1055/s-0032-1304569
Mini-Review Series on Diabetes and its Complications
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Murine Models of Diabetic Nephropathy

V. Peters
1   Division of Metabolic Diseases, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
,
C. P. Schmitt
2   Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
› Author Affiliations
Further Information

Publication History

received 19 January 2012
first decision 19 January 2012

accepted 30 January 2012

Publication Date:
08 March 2012 (online)

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Abstract

Diabetic nephropathy is the leading cause of end stage renal diseases worldwide. Even though several diabetic animal models exist, not a single one develops renal changes sufficiently reflecting those seen in humans. This review provides an overview on mouse models presenting with various features of diabetic nephropathy. The critical analysis and comparison of existing mouse models substantially enhances our understanding of the disease process and should provide a guide for choosing the most suitable mouse model for the investigation of diabetic nephropathy.

Key words

diabetes - obesity - leptin
 

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