Murine Models of Diabetic Nephropathy

V. Peters; C. P. Schmitt

doi:10.1055/s-0032-1304569

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2012; 120(04): 191-193
DOI: 10.1055/s-0032-1304569

Mini-Review Series on Diabetes and its Complications

Murine Models of Diabetic Nephropathy

Autor*innen

V. Peters

¹Division of Metabolic Diseases, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany
C. P. Schmitt

²Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany

Abstract

Diabetic nephropathy is the leading cause of end stage renal diseases worldwide. Even though several diabetic animal models exist, not a single one develops renal changes sufficiently reflecting those seen in humans. This review provides an overview on mouse models presenting with various features of diabetic nephropathy. The critical analysis and comparison of existing mouse models substantially enhances our understanding of the disease process and should provide a guide for choosing the most suitable mouse model for the investigation of diabetic nephropathy.

Key words

diabetes - obesity - leptin

Volltext

Referenzen

References
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