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Exp Clin Endocrinol Diabetes 2012; 120(04): 199-201
DOI: 10.1055/s-0032-1304571
DOI: 10.1055/s-0032-1304571
Mini-Review Series on Diabetes and its Complications
Crosstalk in the Retinal Neurovascular Unit – Lessons for the Diabetic Retina
Weitere Informationen
Publikationsverlauf
received 20. Januar 2012
first decision 20. Januar 2012
accepted 30. Januar 2012
Publikationsdatum:
08. März 2012 (online)
![](https://www.thieme-connect.de/media/eced/201204/lookinside/thumbnails/10.1055-s-0032-1304571-1.jpg)
Abstract
Diabetic retinopathy shares important features with neurodegenerative retinal diseases, including loss of ganglion cells and retinal thinning. The impact on vasoregression and subsequent ischemia-driven changes such as macular edema and proliferative retinopathy are not established. Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2(1/703)HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.
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