Myeloperoxidase Levels Predict Executive Function

H. Haslacher; T. Perkmann; I. Lukas; A. Barth; E. Ponocny-Seliger; M. Michlmayr; V. Scheichenberger; O. Wagner; R. Winker

doi:10.1055/s-0032-1304637

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(12): 1034-1038
DOI: 10.1055/s-0032-1304637

Behavioural Sciences

Myeloperoxidase Levels Predict Executive Function

Authors

H. Haslacher

¹Department of Laboratory Medicine, Medical University of Vienna, Austria
T. Perkmann

¹Department of Laboratory Medicine, Medical University of Vienna, Austria
I. Lukas

²Unit of Occupational Medicine, Medical University of Vienna, Austria
A. Barth

³Division for Health Policy, Administration and Law, UMIT-University for Health Sciences, Medical Informatics and Technology, Hall i. T. , Austria
E. Ponocny-Seliger

⁴Department of Psychology, Sigmund Freud Private University, Vienna, Austria
M. Michlmayr

²Unit of Occupational Medicine, Medical University of Vienna, Austria
V. Scheichenberger

¹Department of Laboratory Medicine, Medical University of Vienna, Austria
O. Wagner

¹Department of Laboratory Medicine, Medical University of Vienna, Austria
R. Winker

⁵Health and Prevention Center, Sanatorium Hera, Vienna, Austria

Abstract

The main purpose of the study was to investigate whether baseline myeloperoxidase (MPO) levels are associated with executive cognitive function in individuals with high physical activity. Baseline serum MPO levels of 56 elderly marathon runners and 58 controls were assessed by ELISA. Standardized tests were applied to survey domain-specific cognitive functions. Changes in brain morphology were visualized by magnetic resonance imaging (MRI). High baseline serum MPO levels correlated with worse outcome in tests assessing executive cognitive function in athletes but not in the control group (NAI maze test p<0.05, Trail Making Test ratio p<0.01). In control participants, subcortical white matter hyperintensities were associated with higher scores on the Geriatric Depression Scale (p<0.05), whereas athletes seem to be protected from this effect. During strenuous exercising, MPO as well as its educts may be elevated due to increased oxygen intake and excretion of pro-inflammatory mediators inducing host tissue damage via oxidative stress. This outweighs the potential benefits of physical activity on cognitive function.

Key words

marathon - exercising - inflammation

Full Text

References

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