Neue Erkenntnisse über die Zelltodregulation: Bedeutung für die Tumorpathologie

Zusammenfassung

Krebszellen haben bestimmte Eigenschaften entwickelt, die ihnen gegenüber normalen Zellen einen Selektionsvorteil sichern. Über Jahrzehnte befasste sich die Krebsforschung mit den molekularen Mechanismen der Apoptose, insbesondere mit Mechanismen zur Überwindung der Apoptoseresistenz von Tumorzellen. Inzwischen sind neue Formen des programmierten Zelltodes für sowohl physiologische als auch pathologische Prozesse bedeutsam. Neueste Forschungsergebnisse lassen erwarten, dass die Auslösung alternativer Zelltodformen wie der Nekroptose eine wichtige Strategie sein könnte, um Apoptose-resistente Tumorzellen wieder für die konventionelle Chemo- und Radiotherapie zu sensibilisieren.

Abstract

During tumorigenesis cancer cells acquire certain features allowing for sustained growth and circumvention of programmed cell death. For decades cancer research has been focused on the molecular mechanisms of apoptosis and how to overcome apoptosis resistance in tumor cells. Meanwhile, novel types of programmed cell death turned out to be important for both physiologic and pathologic processes. Recent findings imply that induction of alternative forms of programmed cell death, such as necroptosis, might be used as a therapeutic approach to overcome therapy resistance in cancer.

Schlüsselwörter

Apoptose - Nekrose - Zelltod - Tumorpathologie

Keywords

apoptosis - necrosis - cell death - tumor pathology

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