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DOI: 10.1055/s-0032-1306321
Physiological, Pathophysiological and Therapeutic Impact of the Enteric Serotonergic System
Publikationsverlauf
received 06. Februar 2012
accepted 21. Februar 2012
Publikationsdatum:
21. März 2012 (online)
![](https://www.thieme-connect.de/media/amf/201204/lookinside/thumbnails/10.1055-s-0032-1306321-1.jpg)
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) induces various effects in the central nervous system, cardiovascular system and gastrointestinal tract. The response depends primarily on the nature of the 5-HT receptors involved. In the light of the current knowledge about the anatomy and physiology of the serotonergic system and the distribution of the various 5-HT receptors in the gut, the established and potential therapeutic impact of 5-HT receptor ligands are discussed. In particular, selective 5-HT receptor ligands influencing intestinal motility and pain perception such as the 5-HT4 receptor agonist prucalopride appear promising for the treatment of irritable bowel syndrome.
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