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Neuroradiologie Scan 2012; 02(02): 111-130
DOI: 10.1055/s-0032-1306773
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© Georg Thieme Verlag KG Stuttgart · New York

Nebenwirkungen von Krebstherapien auf das zentrale Nervensystem von Kindern und Jugendlichen: aktuelle neuroradiologische Befunde[1]

Side effects of oncologic therapies in the pediatric central nervous system: update on neuroimaging findings
Elida Vázquez
,
Ignacio Delgado
,
Angel Sánchez-Montañez
,
Ignasi Barber
,
José Sánchez-Toledo
,
Goya Enríquez
Further Information

Publication History

Publication Date:
11 April 2012 (online)

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Zusammenfassung

Es ist zunehmend wichtig, Komplikationen im ZNS (zentrales Nervensystem), die während und nach pädiatrischen Krebstherapien auftreten, frühzeitig und korrekt zu diagnostizieren, denn die Gesamtüberlebensraten werden dank innovativer und aggressiver onkologischer Therapien immer besser. Höchste Wachsamkeit ist erforderlich, um die radiologischen Merkmale dieser ZNS-Komplikationen zu identifizieren. Der Radiologe muss hierzu mit den früh und spät auftretenden ZNS-Nebenwirkungen von Krebstherapien im Kindes- und Jugendalter vertraut sein (z. B. toxische Effekte, Infektionen, endokrine oder sensorische Dysfunktionen, neuropsychologische Störungen, 2. maligne Erkrankungen), um die bildgestützte Diagnosestellung zu beschleunigen und die assoziierte Morbidität möglichst gering zu halten. Der Ausbau der Kenntnisse über diese Komplikationen wird es ermöglichen, besser zugeschnittene therapeutische Studien zu entwickeln sowie die Patienten effektiver zu überwachen, und so zu einer Steigerung der Lebensqualität durch Verringerung der Folgeschäden bei Überlebenden führen.

Abstract

The need for early, accurate diagnosis of central nervous system (CNS) complications occurring during and after pediatric cancer treatment is growing because of the improvement in overall survival rates related to innovative and aggressive oncologic therapies. An elevated degree of suspicion is needed to recognize the radiologic features of these CNS complications. Radiologists need familiarity with the early and late side effects of cancer therapy in the pediatric CNS (e. g., toxic effects, infection, endocrine or sensory dysfunction, neuropsychologic impairment, second malignancies), in order to accelerate the imaging diagnosis and minimize as much as possible the associated morbidity. Acquisition of knowledge about these complications will enable the development of more appropriate therapeutic trials and more effective patient surveillance and will lead to an improved quality of life by decreasing the long-term sequelae in survivors.

1 © 2011 The Radiological Society of North America. All rights reserved. Originally puplished in English in RadioGraphics 2011; 31: 1123 – 1139. Online puplished in 10.1148 /rg.314105180. Translated and reprinted with permission of RSNA. RSNA is not responsible for any inaccuracy or error arising from the translation from English to German.


 

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