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Exp Clin Endocrinol Diabetes 2012; 120(07): 405-409
DOI: 10.1055/s-0032-1309005
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Thirst Challenge on ADH Levels in Patients with Bilateral Menière’s Disease

S. Steinbach
1   Department of Otolaryngology, Head and Neck Surgery, Universityhospital Giessen and Marburg, Campus Marburg, Marburg, Germany
,
W. Hundt
2    Department of Radiology, Universityhospital Giessen and Marburg, Campus Marburg, Marburg, Germany
,
K. F. Hamann
3    Department of Otolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
,
J. A. Werner
1   Department of Otolaryngology, Head and Neck Surgery, Universityhospital Giessen and Marburg, Campus Marburg, Marburg, Germany
,
R. Mandic
1   Department of Otolaryngology, Head and Neck Surgery, Universityhospital Giessen and Marburg, Campus Marburg, Marburg, Germany
› Author Affiliations
Further Information

Publication History

received 22 December 2011
first decision 22 December 2011

accepted 13 March 2012

Publication Date:
10 May 2012 (online)

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Abstract

The aim of the study was to investigate plasma ADH levels and plasma/urine osmolality in patients suffering from bilateral Menière’s disease since a disturbance in the water household after thirst challenge is a suspected pathogenic factor in the development of this disease. In this study the plasma ADH levels and plasma/urine osmolality of bilateral Menière’s disease patients under thirst challenge were investigated to show whether the water balance is affected. 9 patients with bilateral Menière’s disease and 9 healthy controls skipped water intake for 12 h. Plasma ADH, plasma/urine osmolality, and electrolytes were measured after this thirst period as well as 8 h later after food and fluid intake. During food and fluid intake the patients demonstrated a slightly higher plasma ADH level and plasma osmolality than controls, whereas at the end of the thirst period patients and the controls showed no significant change. Instead the urine osmolality differed significantly (p<0.001): showing a high urine osmolality in controls and an almost stable urine osmolality in patients after thirst challenge. This indicates that the water balance in patients is likely different from that of controls. These observations point to ADH and its target aquaporine 2 as keyplayers in the pathophysiological events leading to the development of Menière’s disease.

Key words

bilateral Menière’s disease - thirst challenge - antidiuretic hormone - plasma osmolality - urine osmolality
 

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