The 2012 Digestive Disease Week meeting (DDW; 19 – 22 May, San Diego, California, USA) brought together the finest gastroenterologists from all over the world. A review of the field of endoscopic retrograde cholangiopancreatography (ERCP) showed there to be a good number of research reports, though no groundbreaking novelties. However, solid data were presented, particularly within the fields of cannulation, post-ERCP pancreatitis (PEP), and altered anatomy techniques. In addition, issues of sedation, quality control, and safety were addressed. Selected abstracts from the meeting are reviewed below.