Early Administration of Low-Dose Aspirin for the Prevention of Severe and Mild Preeclampsia: A Systematic Review and Meta-Analysis

Stéphanie Roberge; Yves Giguère; Pia Villa; Kypros Nicolaides; Merja Vainio; Jean-Claude Forest; Peter von Dadelzen; Daniel Vaiman; Sylvie Tapp; Emmanuel Bujold

doi:10.1055/s-0032-1310527

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2012; 29(07): 551-556
DOI: 10.1055/s-0032-1310527

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Early Administration of Low-Dose Aspirin for the Prevention of Severe and Mild Preeclampsia: A Systematic Review and Meta-Analysis

Stéphanie Roberge

¹Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec, Canada

,

Yves Giguère

²Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Quebec, Canada

,

Pia Villa

³Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

,

Kypros Nicolaides

⁴Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, United Kingdom

,

Merja Vainio

⁵Kanta-Häme Central Hospital, Hämeenlinna, Finland

,

Jean-Claude Forest

²Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Quebec, Canada

,

Peter von Dadelzen

⁶Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

,

Daniel Vaiman

⁷Genomics and Epigenetics of Human Reproduction, Institut Cochin, Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris Descartes, Paris, France

,

Sylvie Tapp

¹Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec, Canada

,

Emmanuel Bujold

⁸Department of Obstetrics and Gynecology, Faculty of Medecine, Université Laval, Quebec, Canada

› Institutsangaben

Abstract

Objective To determine whether early administration of aspirin prevents severe and mild preeclampsia.

Study Design A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated.

Results Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia.

Conclusion Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia.

Keywords

pregnancy - preeclampsia - aspirin - systematic review - meta-analysis

Volltext

Referenzen

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