Effects of Supervised Exercise on Gamma-Glutamyl Transferase Levels in Patients with Isolated Impaired Fasting Glucose and Those with Impaired Fasting Glucose Plus Impaired Glucose Tolerance

M. Burtscher; H. Gatterer; T. Dünnwald; D. Pesta; M. Faulhaber; N. Netzer; R. Koch; K. König; H. Ulmer

doi:10.1055/s-0032-1311642

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2012; 120(08): 445-450
DOI: 10.1055/s-0032-1311642

Article

Effects of Supervised Exercise on Gamma-Glutamyl Transferase Levels in Patients with Isolated Impaired Fasting Glucose and Those with Impaired Fasting Glucose Plus Impaired Glucose Tolerance

M. Burtscher

¹Department of Sport Science, Medical Section, University of Innsbruck, Austria

,

H. Gatterer

¹Department of Sport Science, Medical Section, University of Innsbruck, Austria

,

T. Dünnwald

¹Department of Sport Science, Medical Section, University of Innsbruck, Austria

,

D. Pesta

¹Department of Sport Science, Medical Section, University of Innsbruck, Austria

,

M. Faulhaber

¹Department of Sport Science, Medical Section, University of Innsbruck, Austria

,

N. Netzer

²Hermann Buhl Institute for Hypoxia and Sleep Medicine Research, Paracelsus Medical University, Salzburg, Austria

,

R. Koch

³Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University Innsbruck, Austria

,

K. König

⁴General practitioner, Vorarlberg, Austria

,

H. Ulmer

⁵Department of Medical Statistics, Informatics and Health Economics, Medical University Innsbruck, Austria

› Institutsangaben

Abstract

Aim:

To study the effects of a supervised exercise program on serum gamma-glutamyl transferase (GGT), glycemic control and cardiovascular risk factors in pre-diabetic patients with isolated impaired fasting glucose (IFG) and those with IFG plus impaired glucose tolerance (IGT).

Methods:

Out of 60 pre-diabetic patients (30 with isolated IFG and 30 with IFG + IGT) 24 were randomly assigned to the supervised exercise program (1 h twice a week) and 36 only obtained counselling on the risk of diabetes and its prevention. Patients have been followed over a 12-month period.

Results:

The main findings were that patients with IFG + IGT had increased GGT levels at baseline (49.2±27.4 U/L) compared to subjects with isolated IFG (28.1±21.9 U/L) (p<0.01), and that GGT levels improved only after the supervised exercise intervention within the IFG + IGT subjects ( − 17.7±19.6 U/L). Similarly, baseline triglyceride levels were also higher in IFG + IGT patients (p<0.001) and there was a decrease through exercise intervention in these patients only (p<0.05).

Conclusion:

GGT is an unspecific marker of oxidative stress and both high plasma glucose and triglycerides levels may produce oxidative stress. Thus, patients with IFG + IGT seem to have higher levels of oxidative stress than those with isolated IFG. Based on the known association between GGT levels and cardiovascular risk factors, IFG + IGT patients may be at higher risk for the development of cardiovascular diseases. The specific effect of regular exercise on GGT in pre-diabetic patients may contribute to the understanding of the preventive effects related to exercise.

Key words

gamma-glutamyl transferase - impaired fasting glucose - impaired glucose tolerance - exercise - cardiovascular risk factors

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Referenzen

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