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ZWR - Das Deutsche Zahnärzteblatt 2012; 121(3): 78-88
DOI: 10.1055/s-0032-1311748
Wissenschaft
Prophylaxe
© Georg Thieme Verlag Stuttgart · New York

Zur antimikrobiellen Wirkung von NaF-haltigen Zahnpasten

Antimicrobial Efficacy of NaF-Toothpastes
S Kneist
,
C Sieckmann
,
H Küpper
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Publikationsverlauf

Publikationsdatum:
31. März 2012 (online)

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Einer synergistischen antimikrobiellen Wirkung von 106 NaF-Zahnpasten auf Mikroorganismen des supra- und subgingivalen Biofilms wurde mit dem Agar-Hemmhof-Test nachgegangen. NaF-Zahnpasten mit Zink/Zinn lösten im Mittel Hemmhofzonen gleich Zahnpasten mit NaF allein oder mit natürlichen Wirkstoffen oder Zink aus. Die Wirkung der NaF-Zahnpasten mit Triclosan war am stärksten ausgeprägt. Ob die remineralisierende Wirkung der Zahnpasten in vivo von einer antimikrobiellen Wirkung begleitet ist, bleibt offen.

The antimicrobial efficacy of ingredients in toothpastes with NaF on the synergistic reduction of supra- and subgingival biofilms was determined in vitro. The agar diffusion assay was performed with reference strains. Toothpastes with zinc/tin produced no significantly larger inhibition zones compared with those with NaF or natural antimicrobials or zinc. Triclosan-toothpastes caused the largest inhibition zones. The in vivo implication of the results is still not clear.

Schlüsselwörter

In-vitro-Studie - Zahnpasten - NaF - antimikrobielle Wirkung - sensibles Keimspektrum

Key words

In Vitro Study - Toothpastes - NaF - Antimicrobial Efficacy - Susceptibility Among Germs
 

  • Literatur

  • 1 Ainamo JI. The effect of habitual toothcleaning on the occurrence of periodontal disease and dental caries. Suom Hammaslaak Toim 1971; 67: 63-70
    PubMedGoogle Scholar
  • 2 Arends J et al. Effect of various fluorides on enamel structure and chemistry. In: Guggenheim B, Hrsg. Cariology Today. Basel: Karger; 1984: 245-258
    Google Scholar
  • 3 Arends J, ten Bosch JJ. In vivo de- and remineralization of dental enamel. In: Leach SA, Hrsg. Factors relating to demineralization and remineralization of teeth. Oxford (Großbritannien) Washington D.C.: IRL Press; 1986: 1-11
    Google Scholar
  • 4 Ashley PF, Attrill DC, Ellwood RP et al. Toothbrushing habits and caries experience. Caries Res 1999; 33: 401-402
    CrossrefPubMedGoogle Scholar
  • 5 Beals D, Ngo T, Feng Y et al. Development and laboratory evaluation of a new toothbrush with a novel brush head design. Am J Dent 2000; 13
    PubMedGoogle Scholar
  • 6 Buzalaf MAR et al. Mechanism of action of fluoride for Carie control. In: Buzalaf MAR, Hrsg. Fluoride and the oral environment. Basel: Karger; 2011: 97-114
    CrossrefGoogle Scholar
  • 7 Chestnut IG, Schafer F, Jacobsen APM et al. The influence of toothbrushing frequency and post-brushing rinsing on caries experience in a clinical trial. Community Dent Oral Epidemiol 1998; 26: 406-411
    CrossrefPubMedGoogle Scholar
  • 8 Clarkson J, Hardwick K, Barmes D et al. International collaborative research on fluoride. J Dent Res 2000; 79: 893-904
    CrossrefPubMedGoogle Scholar
  • 9 Davies RM, Ellwood RP, Davies GM. The effectiveness of a toothpaste containing triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health: a systematic review. J Clin Periodontol 2004; 31: 1029-1033
    CrossrefPubMedGoogle Scholar
  • 10 Den Besten P, Ko HS. Fluoride levels in whole saliva of preschool children after brushing with 0.25 g (pea-sized) as compared to 1.0 g (full-brush) of a fluoride dentifrice. Pediatr Dent 1996; 18: 277-280
    PubMedGoogle Scholar
  • 11 Duckworth RM, Morgan SN, Gilbert RJ. Oral fluoride measurements for estimation of the anti-caries efficacy of fluoride treatments. J Dent Res 1992; 71: 836-840
    PubMedGoogle Scholar
  • 12 Duckworth RM, Morgan SM, Burchell CK. Fluoride in plaque following use of dentifrices containing NaMFP. J Dent Res 1998; 68: 130-133
    PubMedGoogle Scholar
  • 13 Duke SA, Forward GC. The conditions occurring in vivo when brushing with toothpastes. Br Dent J 1982; 152: 52-54
    CrossrefPubMedGoogle Scholar
  • 14 Emling RC, Flickinger KC, Cohen DW et al. Comparison of estimated versus actual brushing time. Pharmacol Ther Dent 1991; 6: 93-98
    PubMedGoogle Scholar
  • 15 Glass RL. The first international conference on the declining prevalence of dental caries. J Dent Res 1982; 61: 1301-1383
    PubMedGoogle Scholar
  • 16 Gülzow HJ, Hellwig E, Hetzer G. Empfehlungen zur Kariesprophylaxe mit Fluoriden. Dtsch Zahnärztl Z 2000; 55: 383-383
    PubMedGoogle Scholar
  • 17 Gülzow HJ et al. Kurzfassung Leitlinie Fluoridierungsmaßnahmen. (Hrsg.) Zahnärztliche Zentralstelle Qualitätssicherung (ZZQ) im Institut der Deutschen Zahnärzte. Köln. 2006: 6-7
    PubMedGoogle Scholar
  • 18 Hamilton IR, Bowden GHW. Fluoride effects on oral bacteria. In: Fejerskov O, Ekstrand J, Burt BA., Hrsg. Fluoride in Dentistry, ed 2. Copenhagen, Mukunsgaard: Blackwell; 1996: 230-251
    Google Scholar
  • 19 Hellwege K-D. Die neuen Zahnpasten – Was ist eigentlich dran?. Quintessenz Team J 2010; 40: 179-189
    PubMedGoogle Scholar
  • 20 Kilian M, Larsen MJ, Fejerskov O et al. Effects of fluoride on the initial colonization of teeth in vivo. Caries Res 1979; 13: 319-329
    CrossrefPubMedGoogle Scholar
  • 21 Kilian M, Thystrup A, Fejerskov O. Predominant plaque flora of Tanzanian children exposed to high and low water fluoride concentratopns. Caries Res 1979; 13: 330-343
    CrossrefPubMedGoogle Scholar
  • 22 Koga H, Yamagishi A, Takayanagi A et al. Estimation of optimal amount of fluoride dentifrice for adults to prevent caries by comparison between fluoride uptake into enamel in vitro and fluoride concentration in fluid in vivo. Bull Tokyo Dent Coll 2007; 48: 119-128
    CrossrefPubMedGoogle Scholar
  • 23 Limeback H. Appropriate use of fluoride supplements for the prevention of dental caries. Consensus Conference of the Canadian Dental Association. Toronto, Canada, 28–29 November 1997. Introduction. Community Dent Oral Epidemiol 1999; 27: 27-30
    CrossrefPubMedGoogle Scholar
  • 24 Lynch RJ, Navada R, Walia R. Low-levels of fluoride in plaque and saliva and their effects on the demineralisation and remineralisation of enamel; role of fluoride toothpastes. Int Dent J 2004; 54: 304-309
    PubMedGoogle Scholar
  • 25 Macgregor IDM, Rugg-Gunn AJ. Toothbrushing duration in 60 uninstructed young adults. Community Dent Oral Epidemiol 1985; 13: 121-122
    CrossrefPubMedGoogle Scholar
  • 26 Macgregor IDM, Rugg-Gunn AJ. Effect of filming on toothbrushing performance in uninstructed adults in north-east England. Community Dent Oral Epidemiol 1986; 14: 320-322
    CrossrefPubMedGoogle Scholar
  • 27 Makuch A. Die Herausbildung von zahnhygienischen Verhaltensweisen im frühen Kindesalter. Oralprophylaxe 2008; 30: 26-29
    PubMedGoogle Scholar
  • 28 Marinho VCC, Higgins JPT, Logan S et al. Fluoride toothpastes for preventing dental caries in children and adolescents [Review]. Cochrane Database Syst Rev CD 002278 2003; 1
    PubMedGoogle Scholar
  • 29 Olsson J, Odham G. Effect of inorganic ions and surface active organic compounds on the adherence of oral streptococci. Scand J Dent Res 1978; 86: 108-117
    PubMedGoogle Scholar
  • 30 Saxer UP, Barbakow J, Yankell SL. New studies on estimated and actual toothbrushing times and dentifrice use. J Clin Dent 1998; 9: 49-51
    PubMedGoogle Scholar
  • 31 Schiffner U. Fluorid in der Kariesprophylaxe. ZWR – Das deutsche Zahnärzteblatt 2007; 116: 165-172
    PubMedGoogle Scholar
  • 32 Sjögren K, Birkhed D. Factors related to fluoride retention after toothbrushing and possible connection to caries activity. Caries Res 1993; 27: 474-477
    CrossrefPubMedGoogle Scholar
  • 33 Sjörgren K, Birkhed D, Rangmar S et al. Fluoride in the interdental area after two different post-brushing rinsing procedures. Caries Res 1996; 30: 194-199
    CrossrefPubMedGoogle Scholar
  • 34 Splieth CH., Fleßa S. Modelling lifelong costs of caries with and without fluoride use. Eur J Oral Sci 2008; 116: 164-169
    CrossrefPubMedGoogle Scholar
  • 35 Takahashi N, Nyvad B. Caries ecology revisited: Microbial dynamics and the caries process. Caries Res 2008; 42: 409-418
    CrossrefPubMedGoogle Scholar
  • 36 van der Weijden FA, Timmermann MF, Snoek IM et al. Toothbrushing duration and plaque removing efficacy of electric toothbrushes. Am J Dent 1996; 9: 31-36
    PubMedGoogle Scholar
  • 37 Waraaswapati N, Krongnawakul D, Jiraviboon D et al. The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. J Clin Periodontol 2005; 32: 53-58
    CrossrefPubMedGoogle Scholar
  • 38 Watson PS, Pontefract HA, Devine DA et al. Penetration of fluoride into natural plaque biofilms. J Dent Res 2005; 84: 451-455
    CrossrefPubMedGoogle Scholar
  • 39 Zeedyk MS, Longbottom C, Pitts NB. Tooth-brushing practices of parents and toddlers: A study of home-based videotaped sessions. Caries Res 2005; 39: 27-33
    CrossrefPubMedGoogle Scholar
  • 40 Zero DT, Raubertas RF, Fu J et al. Fluoride concentrations in plaque, whole saliva, and ductal saliva after application of home-use topical fluorides. J Dent Res 1992; 71: 1768-1775
    CrossrefPubMedGoogle Scholar
  • 41 Zero DT, Creeth JE, Bosma ML et al. The effect of brushing time and dentifrice quantity on fluoride delivery in vivo and enamel surface microhardness in situ. Caries Res 2010; 44: 90-100
    CrossrefPubMedGoogle Scholar