Juvenile Psammomatoid Ossifying Fibroma of the Forehead, Radical Resection, and Defect Coverage with a Hydroxyl-Apatite Composite—A Case Report

Conclusion

In JPOF, radical resection is the gold standard treatment. Enucleation or curettage might be attempted, however be aware of recurrence of the lesion, as we experienced and as is described in the literature. Covering the defect with a hydroxyl-apatite ceramic implant in children is also an elegant strategy with an excellent cosmetic result.

• References

• 1 Slootweg PJ, El-Mofty SK. Ossifying fibroma. In: Barnes L, Eveson JW, Reichart P, et al, eds. World Health Organization Classification of Tumors. Pathology and Genetics, Head and Neck Tumors. Lyon: IARC Press; 2005: 319-320
• 2 Eversole R, Su L, ElMofty S. Benign fibro-osseous lesions of the craniofacial complex. A review. Head Neck Pathol 2008; 2 (3) 177-202
• 3 Brannon RB, Fowler CB. Benign fibro-osseous lesions: a review of current concepts. Adv Anat Pathol 2001; 8 (3) 126-143
• 4 Wenig BM, Mafee MF, Ghosh L. Fibro-osseous, osseous, and cartilaginous lesions of the orbit and paraorbital region. Correlative clinicopathologic and radiographic features, including the diagnostic role of CT and MR imaging. Radiol Clin North Am 1998; 36 (6) 1241-1259 , xii
• 5 Wenig BM, Vinh TN, Smirniotopoulos JG, Fowler CB, Houston GD, Heffner DK. Aggressive psammomatoid ossifying fibromas of the sinonasal region: a clinicopathologic study of a distinct group of fibro-osseous lesions. Cancer 1995; 76 (7) 1155-1165
• 6 El-Mofty S. Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93 (3) 296-304
• 7 Mafee MF, Yang G, Tseng A, Keiler L, Andrus K. Fibro-osseous and giant cell lesions, including brown tumor of the mandible, maxilla, and other craniofacial bones. Neuroimaging Clin N Am 2003; 13 (3) 525-540
• 8 Johnson LC, Yousefi M, Vinh TN, Heffner DK, Hyams VJ, Hartman KS. Juvenile active ossifying fibroma. Its nature, dynamics and origin. Acta Otolaryngol Suppl 1991; 488: 1-40
• 9 Sawyer JR, Tryka AF, Bell JM, Boop FA. Nonrandom chromosome breakpoints at Xq26 and 2q33 characterize cemento-ossifying fibromas of the orbit. Cancer 1995; 76 (10) 1853-1859
• 10 Della Puppa A, Mottaran R, Scienza R. Image-guided cranial osteoma resection and bioceramic porous hydroxyapatite custom-made reconstruction in a one-step surgical procedure. Technical notes and illustrative case. Acta Neurochir (Wien) 2010; 152 (1) 155-159
• 11 Ko MW, Liu GT. Pediatric idiopathic intracranial hypertension (pseudotumor cerebri). Horm Res Paediatr 2010; 74 (6) 381-389
• 12 Spennato P, Ruggiero C, Parlato RS , et al. Pseudotumor cerebri. Childs Nerv Syst 2011; 27 (2) 215-235
• 13 Schexnayder LK, Chapman K. Presentation, investigation and management of idiopathic intracranial hypertension in children. Current Paediatrics 2006; 16: 336-341
• 14 Smith SF, Newman L, Walker DM, Papadopoulos H. Juvenile aggressive psammomatoid ossifying fibroma: an interesting, challenging, and unusual case report and review of the literature. J Oral Maxillofac Surg 2009; 67 (1) 200-206
• 15 Slootweg PJ, Müller H. Juvenile ossifying fibroma. Report of four cases. J Craniomaxillofac Surg 1990; 18 (3) 125-129
• 16 Waldron CA. Fibro-osseous lesions of the jaws. J Oral Maxillofac Surg 1993; 51 (8) 828-835
• 17 Kelly PR. Poster 014: interferon alpha therapy for aggressive juvenile ossifying fibroma. J Oral Maxillofac Surg 2008; 66 (Suppl) 76-77
• 18 Toyosawa S, Yuki M, Kishino M , et al. Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol 2007; 20 (3) 389-396
• 19 Patel MM, Wilkey JF, Abdelsayed R, D'Silva NJ, Malchoff C, Mallya SM. Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109 (5) 739-743
• 20 Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 1991; 325 (24) 1688-1695
• 21 Schwindinger WF, Francomano CA, Levine MA. Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci U S A 1992; 89 (11) 5152-5156
• 22 de Oliveira RS, Brigato R, Madureira JF , et al. Reconstruction of a large complex skull defect in a child: a case report and literature review. Childs Nerv Syst 2007; 23 (10) 1097-1102
• 23 Brevi BC, Magri AS, Toma L, Sesenna E. Cranioplasty for repair of a large bone defect with autologous and homologous bone in children. J Pediatr Surg 2010; 45 (4) E17-E20
• 24 Friedman DI, Jacobson DM. Idiopathic intracranial hypertension. J Neuroophthalmol 2004; 24 (2) 138-145
• 25 Bruce BB, Biousse V, Newman NJ. Update on idiopathic intracranial hypertension. Am J Ophthalmol 2011; 152 (2) 163-169
• 26 Karahalios DG, Rekate HL, Khayata MH, Apostolides PJ. Elevated intracranial venous pressure as a universal mechanism in pseudotumor cerebri of varying etiologies. Neurology 1996; 46 (1) 198-202
• 27 Honorat R, Marchandot J, Tison C, Cances C, Chaix Y. [Treatment and prognosis of idiopathic intracranial hypertension in children. Retrospective study (1995–2009) and literature review]. Arch Pediatr 2011; 18 (11) 1139-1147
• 28 Soler D, Cox T, Bullock P, Calver DM, Robinson RO. Diagnosis and management of benign intracranial hypertension. Arch Dis Child 1998; 78 (1) 89-94
• 29 Mollan SP, Ball AK, Sinclair AJ , et al. Idiopathic intracranial hypertension associated with iron deficiency anaemia: a lesson for management. Eur Neurol 2009; 62 (2) 105-108