Two Different Primary Brain Tumors, Glioblastoma Multiforme and Pituitary Adenoma, in Association with Colorectal Carcinoma – An Unusual Case of Nonfamilial Turcot's Syndrome?^[*]

Introduction

The coincidence of multiple primary brain tumors of different histological type, though rare, is a known phenomenon in the literature. We describe a single case of a patient harboring glioblastoma multiforme (GBM) and pituitary adenoma (PA) in association with colorectal carcinoma (CC).

^* This article was originally published online in Central European Neurosurgery on July 6, 2011 (DOI:10.1055/s-0031-1279750)

• References

• 1 Groden J. Colon-cancer genes and brain tumors. N Engl J Med 1995; 332: 884-885
• 2 Radin R, Fortgang KC, Zee C , et al. Turcot syndrome: a case with spinal cord and colonic neoplasms. AJR 1984; 142: 475-476
• 3 Burt RW. Polyposis syndromes. In: Yamada T, Alpers DH, Owyang C, Powell DW, Silverstein FE, eds. Textbook of gastroenterology. Vol. 2. Philadelphia: J. B. Lippincott; 1991: 1674-1696
• 4 Hamilton SR, Liu B, Parsons RE , et al. The molecular basis of Turcot's syndrome. N Engl J Med 1995; 332 (13) 839-847
• 5 Mori T, Nagase H, Horii A , et al. Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors. Genes Chromosomes Cancer 1994; 9 (3) 168-172
• 6 Okamoto H, Mineta T, Nakahara Y , et al. Molecular analysis of astrocytoma associated with Turcot syndrome type 1. Case report. Neur Med Chir (Tokyo) 2004; 44: 124-128
• 7 Russell DS, Rubinstein LJ. Tumours of the meninges and related tissues. In: Russell DS, Rubinstein LJ, eds. Pathology of tumours of the nervous system. 5^th ed. Baltimore, MD: Williams & Wilkins; 1989: 449-532
• 8 Tokunaga T, Shigemori M, Hirohata M , et al. Multiple primary brain tumors of different histological types. Report on two cases. Neurol Med Chir 1991; 31: 141-145
• 9 Matyja E, Kuchna I, Kroh H , et al. Meningiomas and gliomas in juxtaposition: casual or causal coexistence? Report of two cases. Am J Surg Pathol 1995; 19: 37-41
• 10 Nestler U, Schmidinger A, Schulz C , et al. Glioblastoma simultaneously present with meningioma – report of three cases. Zentralbl Neurochir 2007; 68 (3) 145-150
• 11 Furtado SV, Dadlani R, Ghosal N , et al. Co-existing thyrotropin secreting pituitary adenoma and low grade glioma: clinical considerations and literature review. J Neurosurg Sci 2009; 53 (2) 71-75
• 12 Miyagi A, Maeda K, Sugawara T , et al. Triple primary intracranial tumors of different cell types: a case report. No Shinkei Geka 1995; 23 (6) 531-536
• 13 Sorenson BF. Multiple primary tumors of the brain and bowel. Case report. Neurosurg 1972; 36: 93-96
• 14 Pöyhönen L, Heikkinen J, Vehkalahti I. Two different primary tumors of the brain in a patient with breast cancer. Eur J Nucl Med 1979; 4 (6) 483-484
• 15 Welsh JS, Thurman SA, Howard SP. Thymoma and multiple malignancies: a case of five synchronous neoplasms and literature review. Clin Med Res 2003; 1 (3) 227-232
• 16 Brasseur B, Dahan K, Beauloye V , et al. Multiple neoplasia in a 15-year-old girl with familial adenomatous polyposis. J Pediatr Hematol Oncol 2009; 31 (7) 530-532