Bedeutung der Orthomolekularen Medizin in der Geriatrie

Zusammenfassung

Ältere Menschen sind aufgrund von Alterungsprozessen (Organfunktion, Darm, Resorption) und Fehl- bzw. Minderernährung gefährdet für Mikronährstoffmängel. Dies betrifft neben Eiweiß und einigen Aminosäuren besonders Omega-3-Fettsäuren, Magnesium, Zink, Selen, Vitamin B₁₂ und D₃. Weitere wichtige Stoffe wie Natrium, Kalium, Coenzym Q10, Vitamin B₆ und α-Liponsäure müssen beachtet werden. Entsprechende Diagnostik und Ergänzung erscheint nicht nur sinnvoll, sondern im Hinblick auf Protektion chronischer und neurodegenerativer Erkrankungen, Osteoporose, Sturzneigung und Infektionsprophylaxe vital notwendig für ein „rüstiges“ Altern mit hoher Lebensqualität.

Abstract

Older people are at risk due to aging processes (organ function, bowel, absorption) and missing or reduced diet for micronutrient deficiencies. This involves not only protein and some amino acids, particularly omega-3 fatty acids, magnesium, zinc, selenium, vitamin B₁₂ and D₃. Other important substances such as sodium, potassium, coenzyme Q10, vitamin B₆ and α-lipoic acid must be considered. Proper diagnosis and supplementation appears not only reasonable, but in terms of patronage of chronic and neurodegenerative diseases, osteoporosis, tendency to fall and infection prophylaxis vital need for a „good“ aging with high quality of life.

Schlüsselwörter

Ernährung - Orthomolekulare Medizin - Geriatrie - Demenz - Lebensqualität

Keywords

Nutrition - orthomolecular medicine - geriatrics - dementia - quality of life

• Literatur

• 1 Annweiler C, Fantino B, Schott AM et al. Vitamin D insufficiency and mild cognitive impairment: cross-sectional association. Eur J Neurol 2012; 19: 1023-1029
• 2 Burgaz A, Orsini N, Larsson SC, Wolk A. Blood-25-hydroxyvitamin D concentration and hypertension: a meta-analysis. J Hypertens 2011; 29: 636-645
• 3 Ginde AA, Mansbach JM, Camargo CA. Association between serum-25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169: 384-390
• 4 Girodon F, Galan P, Monget AL et al. Min.Vit.Aox. geriatric network. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients. Arch Int Med 1999; 159: 748-754
• 5 Gröber U. Neuroenhancement mit α-Liponsäure. zkm 2012; 1: 45-49
• 6 Jazayeri S et al. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Austr New Zeal J Psychiatry 2008; 42: 192-198
• 7 Jesse S, Ludolph AC. Die Vitamine B1, B6 und B12. Der Nervenarzt 2012; 83: 521-534
• 8 Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr 2012; 66: 411-418
• 9 Lappe JM, Travers-Gustafson D, Davies KM et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007; 85: 1586-1591
• 10 Llewellyn DJ, Langa K, Lang I. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol 2009; 22: 199-195
• 11 Maczureck A, Hager K, Kenklies M et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease. Adv Drug Deliv Rev 2008; 60: 1463-1470
• 12 Nourhashemi F, Gillette-Guyonnet S, Andrieu S. Alzheimer disease: protective factors. Am J Clin Nutr 2000; 71: 643S-649S
• 13 Parkera J, Hashmia O, Dutton D. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. J Maturitas 2009; 65: 225-236
• 14 Rajabally YA, Martey J. Neuropathy in Parkinson disease: prevalence and determinants. Neurology 2011; 77: 1947-1950
• 15 Schaefer EJ, Bongard V, Beiser AS et al. Plasma phosphatidylcholine docoshexaenoic acid content and risk of dementia and Alzheimer disease: the Framingahm Heart Study. Arch Neurol 2006; 63: 1545-1550
• 16 Schilling S. Epidemic vitamin D deficiency among patients in an elderly care rehabilitation facility. Dtsch Arztebl Int 2012; 109: 33-38
• 17 Shults CW, Oakes D, Kieburtz K. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002; 59: 1541-1550
• 18 Turner MK, Hooten WM, Schmidt JE et al. Pain Med 2008; 9: 979-984
• 19 Van Dam F, Van Gool WA. Hyperhomocysteinemia and Alzheimer’s disease: A systematic review. Arch Gerontol Geriatr 2009; 48: 425-430
• 20 Wehr E, Pilz S, Boehm BO et al. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol 2010; 73: 243-248