Primary Malignant Vaginal Melanoma – Case Report and Review of the Literature

Abstract

With fewer than 250 cases published worldwide, primary vaginal melanoma is an extremely rare malignant entity which is mostly diagnosed in advanced stages. The estimated incidence of vaginal melanoma is 0.026/100 000 women per year. The poor prognosis for advanced tumour stages and different therapies used in very limited numbers of patients require precise preoperative staging and a planned interdisciplinary therapeutic approach.

Zusammenfassung

Das primäre Melanom der Vagina ist mit weltweit weniger als 250 publizierten Fällen ein äußerst seltenes Malignom und wird meist erst im fortgeschrittenen Stadium diagnostiziert. Die Inzidenz des vaginalen Melanoms wird auf 0,026/100 000 Frauen pro Jahr geschätzt. Die schlechte Prognose bei oftmals später Diagnosestellung sowie die verschiedenen Therapieansätze bei sehr geringen Fallzahlen erfordern ein exaktes präoperatives Staging und eine interdisziplinäre Therapieplanung.

Key words

vaginal tumour - malignant melanoma - multivisceral resection

Schlüsselwörter

Vaginaltumor - malignes Melanom - multiviszerale Resektion

• References

• 1 Ascierto P, Scala S, Ottaiano A et al. Adjuvant treatment of malignant melanoma: Where are we?. Crit Rev Oncol Hematol 2005; 57: 45-52
• 2 Buchanan DJ, Schlaerth J, Kurosaki T. Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. Am J Obstet Gynecol 1998; 178: 1177-1184
• 3 Chung AF, Casey MJ, Floannery JT et al. Malignant melanoma of the vagina – report of 19 cases. Obstet Gynecol 1980; 55: 720-727
• 4 Gokaslan H, Sismanoglu A, Pekin T et al. Primary malignant melanoma of the vagina: a case report and review of the current treatment options. Eur J Obstet Gynecol Reprod Biol 2005; 121: 243-248
• 5 Gupta D, Malpica A, Deavers MT et al. Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol 2002; 26: 1450-1457
• 6 Irvin WP, Bliss SA, Rice LW et al. Malignant melanoma of the vagina and locoregional control. Gynecol Oncol 1998; 71: 476-480
• 7 Miner TJ, Delgado R, Zeisler J et al. Primary vaginal melanoma: a critical analysis of therapy. Ann Surg Oncol 2003; 11: 34-39
• 8 Morton DL, Wen DR, Cochran AJ. Management of early stage melanoma by intraoperative lymphatic mapping and selective lymphadenectomy. Surg Oncol Clin North Am 1992; 1: 247-259
• 9 Nakagawa S, Koga K, Kugu K et al. The evaluation of the sentinel node successfully conducted in a case of malignant melanoma of the vagina. Gynecol Oncol 2002; 86: 387-389
• 10 Petru E, Nagele F, Czerwenka K et al. Primary malignant melanoma of the vagina: a long term remission following radiation therapy. Gynecol Oncol 1998; 70: 23-26
• 11 Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol 2008; 9: 973-981
• 12 Reid GC, Schmidt RW, Roberts JA et al. Primary melanoma of the vagina: a clinicopathologic analysis. Obstet Gynecol 1989; 74: 190-199
• 13 Satzger I, Küttler U, Völker B et al. Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy – case report and review of the literature. Dermatology 2010; 220: 77-81
• 14 Sugiyamaa VE, Chana JK, Kappb DS. Management of melanomas of the female genital tract. Curr Opin Oncol 2008; 20: 565-569
• 15 Van Nordstrand KM, Lucci JA, Schell M et al. Primary vaginal melanoma: improved survival with radical pelvic surgery. Gynecol Oncol 1994; 55: 234-237
• 16 Weinstock MA. Malignant Melanoma of the vulva and vagina in the United States: patterns of incidence and population-based estimates of survival. Am J Obstet Gynecol 1994; 171: 1225-1230