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Planta Med 2012; 78(14): 1579-1593
DOI: 10.1055/s-0032-1315215
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Structure Elucidation and Inhibitory Effects on NO Production of Clerodane Diterpenes from Ajuga decumbens

Zhanping Sun
1   College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
2   Shenyang Pharmaceutical University, Shenyang, China
,
Yushan Li
2   Shenyang Pharmaceutical University, Shenyang, China
,
Da-qing Jin
3   School of Medicine, Nankai University, Tianjin, China
,
Ping Guo
2   Shenyang Pharmaceutical University, Shenyang, China
,
Jing Xu
1   College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
,
Yuanqiang Guo
1   College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
,
Lei Zhang
1   College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
› Author Affiliations
Further Information

Publication History

received 10 May 2012
revised 25 June 2012

accepted 12 July 2012

Publication Date:
07 August 2012 (online)

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Abstract

Three new clerodane diterpenes (1–3), together with five known analogues (4–8), have been isolated from the whole plants of Ajuga decumbens. Their structures were established by detailed spectroscopic and spectrometric data analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). The inhibitory activities of these diterpenes on LPS-induced NO production were evaluated, and compounds 1–4 and 6–8 showed inhibitory effects.

Key words

Ajuga decumbens - Labiatae - clerodane diterpene inhibitory effects on NO production

Supporting Information

 

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